74 Results for "

mitochondrial oxidative damage

" in MedChemExpress (MCE) Product Catalog:
Products (74)

74 Results for "mitochondrial oxidative damage" in MCE Product Catalog:

166
Mitoquinone mesylate
Mitoquinone mesylate
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166 Publications Verification
Cat. No.: HY-100116A
CAS No.: 845959-50-4
Purity:  99.09%
Synonyms: MitoQ mesylate; MitoQ10 mesylate
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Metabolic Disease Cancer

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .
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10
Lipoamide
Lipoamide
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10 Cited Publications
Cat. No.: HY-B1142
CAS No.: 940-69-2
Synonyms: (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
Category:  

Human Gut Microbiota Metabolites Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NO Synthase

Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
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8
Afzelin
Afzelin
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8 Cited Publications
Cat. No.: HY-N1441
CAS No.: 482-39-3
Synonyms: Kaempferol-3-O-rhamnoside
Category:  

Flavonols Flavonoids  Houttuynia cordata Thunb. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Saururaceae Extract

Target:  

Mitochondrial Metabolism PTEN Autophagy Bacterial

Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .
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6
SB 242084
SB 242084
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6 Cited Publications
Cat. No.: HY-13409
CAS No.: 181632-25-7
Purity:  99.96%
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease Metabolic Disease

SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage .
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6
Isobavachin
Isobavachin
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6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
Category:  

Flavonoids Neurological Disease Flavonones Phenols Polyphenols Leguminosae Extract Psoralea corylifolia L. Plants Disease Research Fields

Target:  

Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy

Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .
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6
SB 242084 dihydrochloride
SB 242084 dihydrochloride
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6 Cited Publications
Cat. No.: HY-13409A
CAS No.: 1049747-87-6
Purity:  98.12%
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease Metabolic Disease

SB 242084 dihydrochloride is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage .
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2
Pyraclostrobin
Pyraclostrobin
0 Images
2 Cited Publications
Cat. No.: HY-N6626
CAS No.: 175013-18-0
Target:  

Environmental Pollutants Bacterial Bcl-2 Family Fungal Autophagy mTOR Beclin1 AMPK

Research Areas:  

Infection Metabolic Disease

Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases .
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2
Acetyl-L-carnitine hydrochloride
Acetyl-L-carnitine hydrochloride
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2 Cited Publications
Cat. No.: HY-B0762
CAS No.: 5080-50-2
Synonyms: O-Acetyl-L-carnitine hydrochloride; ALCAR hydrochloride
Category:  

Endogenous metabolite

Target:  

Caspase Apoptosis

Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression .
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2
Acetyl-L-carnitine
Acetyl-L-carnitine
0 Images
2 Cited Publications
Cat. No.: HY-113218
CAS No.: 3040-38-8
Purity:  ≥98.0%
Synonyms: O-Acetyl-L-carnitine; ALCAR
Category:  

Natural Products Animals

Target:  

Caspase Apoptosis

Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression .
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2
Phellodendrine chloride
Phellodendrine chloride
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2 Cited Publications
Cat. No.: HY-N0735
CAS No.: 104112-82-5
Category:  

Rutaceae Extract Alkaloids Phellodendron amurense Rupr. Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Autophagy Apoptosis AMPK mTOR STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP

Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway .
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2
Oleanonic acid
Oleanonic acid
0 Images
2 Cited Publications
Cat. No.: HY-N1487
CAS No.: 17990-42-0
Synonyms: 3-Oxooleanolic acid
Category:  

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Cancer

Target:  

HIV Autophagy Ferroptosis Amyloid-β

Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .
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1
84-B10
84-B10
0 Images
1 Cited Publications
Cat. No.: HY-44307
CAS No.: 698346-43-9
Target:  

Ferroptosis

Research Areas:  

Cancer

84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI) .
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1
3-Methylcrotonylglycine
3-Methylcrotonylglycine
0 Images
1 Cited Publications
Cat. No.: HY-113232
CAS No.: 33008-07-0
Purity:  99.90%
Category:  

Disease markers Metabolic Disease Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Na+/K+ ATPase Mitochondrial Metabolism

3-Methylcrotonylglycine is an organic acid conjugate associated with leucine catabolism that inhibits respiratory chain complex II-III, mitochondrial creatine kinase, and synaptic membrane Na +, K +-ATPase. 3-Methylcrotonylglycine increases reactive oxygen species levels to mediate oxidative damage, while inhibiting mitochondrial electron transport, reducing tricarboxylic acid cycle flux, and interfering with intracellular energy transport and neuronal ion homeostasis. 3-Methylcrotonylglycine is a neurotoxic metabolite that accumulates in the metabolic pathway of 3-methylcrotonyl-CoA carboxylase deficiency. 3-Methylcrotonylglycine can be used in studies related to 3-methylcrotonyl-CoA carboxylase deficiency .
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Fusaric acid
Fusaric acid
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Cat. No.: HY-128483
CAS No.: 536-69-6
Purity:  99.94%
Category:  

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:  

TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor

Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .
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Ginkgo biloba extract
Ginkgo biloba extract
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Cat. No.: HY-N12060
CAS No.: 90045-36-6
Category:  

Natural Products Ginkgoaceae Extract Ginkgo biloba L. Plants

Target:  

Bcl-2 Family Caspase Apoptosis Autophagy Reactive Oxygen Species (ROS) Akt JNK ERK

Ginkgo biloba extract is a natural product that can be isolated from Ginkgo biloba leaves . Ginkgo biloba extract alleviates oxidative stress-induced neuronal apoptosis (Apoptosis) by stabilizing mitochondrial function, regulating Bcl-2 family proteins and inhibiting caspase activation. Ginkgo biloba extract alleviates testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy (Autophagy) . Ginkgo biloba extract alleviates various types of neuronal damage in animal models. Ginkgo biloba extract reduces behavioral sensitization in rats. Ginkgo biloba extract counteracts Aβ-induced neurotoxicity by blocking a series of Aβ-triggered events, including glucose uptake, ROS accumulation, AKT activation, mitochondrial dysfunction, JNK and ERK 1/2 pathways, and apoptosis, and also interferes with the formation of Aβ oligomers. Ginkgo biloba extract is applicable to research related to cerebral hypoperfusion, testicular injury, Alzheimer's disease, Parkinson's disease, multi-infarct dementia, stroke, traumatic brain injury and amyotrophic lateral sclerosis .
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3-Methylglutaric acid
3-Methylglutaric acid
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Cat. No.: HY-113410
CAS No.: 626-51-7
Purity:  ≥98.0%
Category:  

Metabolic Disease Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder

Target:  

Na+/K+ ATPase Mitochondrial Metabolism Reactive Oxygen Species (ROS)

3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na +, K +-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na +, K +-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration .
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Acetyl-L-carnitine-d3 hydrochloride
Acetyl-L-carnitine-d3 hydrochloride
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Cat. No.: HY-B0762S
CAS No.: 1334532-17-0
Synonyms: O-Acetyl-L-carnitine-d3 hydrochloride
Acetyl-L-carnitine-d3 (O-Acetyl-L-carnitine-d3) hydrochloride is the deuterium labeled Acetyl-L-carnitine hydrochloride (HY-B0762). Acetyl-L-carnitine (O-Acetyl-L-carnitine; ALCAR) hydrochloride is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier. Acetyl-L-carnitine hydrochloride selectively enters cells and the brain through the organic cation transporter OCTN2. Acetyl-L-carnitine hydrochloride can participate in fatty acid β-oxidation, promote acetylcholine synthesis, regulate mitochondrial function and inhibit oxidative stress as an acetyl donor. Acetyl-L-carnitine hydrochloride exerts its activity by enhancing energy metabolism, protecting neurons and improving synaptic plasticity. Acetyl-L-carnitine hydrochloride is mainly used in the study of neurodegenerative diseases and metabolic disorder-related diseases such as neonatal hypoxic-ischemic brain damage, Alzheimer's disease, and depression .
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Schisanhenol
Schisanhenol
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Cat. No.: HY-N0859
CAS No.: 69363-14-0
Synonyms: Schizanhenol; Gomisin-K3
Category:  

Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Extract Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

UGT Cholinesterase (ChE) Tau Protein SOD Sirtuin

Schisanhenol (Schizanhenol), a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits UGT2B7 activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration .
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Evernic Acid
Evernic Acid
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Cat. No.: HY-121362
CAS No.: 537-09-7
Purity:  99.71%
Category:  

Ketones, Aldehydes, Acids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

Bacterial Endogenous Metabolite TrxR

Evernic Acid is an orally active thioredoxin reductase 1 (TrxR1) inhibitor and antiproliferative agent. Evernic Acid inhibits the proliferation and migration of human breast cancer cells. Evernic Acid blocks the NF-κB pathway by inhibiting p65 nuclear translocation and IκBα phosphorylation, thereby suppressing downstream inflammatory mediators. Evernic Acid acts as an antioxidant, anti-inflammatory agent and neuroprotective agent, protects neurons from cell death, mitochondrial dysfunction and oxidative stress damage, reduces astrocyte activation, and ameliorates dopaminergic neuron loss and neuroinflammation. Evernic Acid inhibits enoyl reductases FabI and FabZ of Plasmodium falciparum. Evernic Acid downregulates the expression of lasB and rhlA genes in Pseudomonas aeruginosa, inhibits quorum sensing and biofilm formation, and exerts antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungi. Evernic Acid is applicable to research related to breast cancer, Parkinson's disease, bacterial infections and fungal infections .
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Hydroxyacetone
Hydroxyacetone
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Cat. No.: HY-Y1366
CAS No.: 116-09-6
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Mitochondrial Metabolism Reactive Oxygen Species (ROS) Arp2/3 Complex Apoptosis

Hydroxyacetone is a toxic compound. Hydroxyacetone can be isolated from e-cigarette aerosols. Hydroxyacetone reduces the activity of cellular Mitochondrial reductase (with an IC50 of 5.53 mg/mL for mitochondrial reductase in BEAS-2B cells) and increases ROS levels. Hydroxyacetone induces mitochondrial stress and oxidative damage. Hydroxyacetone induces destabilization of F-actin. At high concentrations, Hydroxyacetone promotes cell rounding and Apoptotic body formation. Hydroxyacetone exerts toxic effects on cells including airway epithelial cells and possesses respiratory toxicity potential .\n
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