Aminoacetone hydrochloride

Name: Aminoacetone hydrochloride
Brand: MedChemExpress
SKU: HY-W004850
Rating: 4.5 (1 reviews)

Cat. No.: HY-W004850 Purity: 98.0%: Data Sheet
COA

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Handling Instructions
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Aminoacetone hydrochloride is an α-aminoketone and also a catabolite of threonine and glycine. When accumulated under pathological conditions, Aminoacetone hydrochloride participates in oxidative damage and protein dysfunction via the production of reactive oxygen species (ROS) and methylglyoxal, and it is associated with phenotypes such as diabetes, mitochondrial damage and sleep disorders.

For research use only. We do not sell to patients.

Aminoacetone hydrochloride Chemical Structure

CAS No. : 7737-17-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
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Description

In Vitro

Aminoacetone (0.15-1.0 mM) induces dose-dependent, calcium-mediated swelling in isolated rat liver mitochondria, with 1.0 mM causing maximal swelling that is prevented by EGTA, MgCl₂, or high-dose cyclosporine A^[2].
Aminoacetone (0.2-1 mM) dose-dependently inhibits succinate-sustained oxygen consumption in isolated rat liver mitochondria, with 1 mM reducing the consumption rate from 9.1 to 0.7 nmol oxygen/min, via reactive oxygen species-mediated mechanisms^[2].
Aminoacetone (0.5 mM; 20 min) reduces total protein thiol content by 31.8% in isolated rat liver mitochondria and induces formation of membrane protein aggregates, effects that are reversed by dithiothreitol^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

109.55

Formula

C₃H₈ClNO

CAS No.

7737-17-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(CN)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1825.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.1283 mL	45.6413 mL	91.2825 mL
5 mM	1.8257 mL	9.1283 mL	18.2565 mL
10 mM	0.9128 mL	4.5641 mL	9.1283 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: 98.0%

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Data Sheet (272 KB) SDS (476 KB)

COA (247 KB) HNMR (224 KB) MS (82 KB)

Handling Instructions (2659 KB)

References

[1]. Zhou S, et al. Aminoacetone is associated with sleep latency. Sleep Med. 2025;128:183-186. [Content Brief]

[2]. Dutra F, et al. Aminoacetone induces iron-mediated oxidative damage to isolated rat liver mitochondria. Arch Biochem Biophys. 2004;430(2):284-289. [Content Brief]

[3]. Ramos LD, et al. Aerobic co-oxidation of hemoglobin and aminoacetone, a putative source of methylglyoxal. Free Radic Biol Med. 2021;166:178-186. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	9.1283 mL	45.6413 mL	91.2825 mL	228.2063 mL
	5 mM	1.8257 mL	9.1283 mL	18.2565 mL	45.6413 mL
	10 mM	0.9128 mL	4.5641 mL	9.1283 mL	22.8206 mL
	15 mM	0.6086 mL	3.0428 mL	6.0855 mL	15.2138 mL
	20 mM	0.4564 mL	2.2821 mL	4.5641 mL	11.4103 mL
	25 mM	0.3651 mL	1.8257 mL	3.6513 mL	9.1283 mL
	30 mM	0.3043 mL	1.5214 mL	3.0428 mL	7.6069 mL
	40 mM	0.2282 mL	1.1410 mL	2.2821 mL	5.7052 mL
	50 mM	0.1826 mL	0.9128 mL	1.8257 mL	4.5641 mL
	60 mM	0.1521 mL	0.7607 mL	1.5214 mL	3.8034 mL
	80 mM	0.1141 mL	0.5705 mL	1.1410 mL	2.8526 mL
	100 mM	0.0913 mL	0.4564 mL	0.9128 mL	2.2821 mL