2. Apoptosis
  3. Ferroptosis
  4. 84-B10

84-B10 

Cat. No.: HY-44307
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84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI).

For research use only. We do not sell to patients.

84-B10 Chemical Structure

84-B10 Chemical Structure

CAS No. : 698346-43-9

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Based on 1 publication(s) in Google Scholar

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Description

84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1].

In Vitro

84-B10 (10-100 μM; 2 h) inhibits cisplatin-induced tubular epithelial cell ferroptosis in a dose-dependent manner[1].
84-B10 (40 μM; 2 h; TKPT cells) restores cisplatin-induced mitochondrial structural damage and dysfunction[1].
84-B10 (40 μM; 2 h; TKPT cells) attenuates mtROS-induced oxidative stress in cisplatin-induced AKI[1].
84-B10 (40 μM; 2 h; TKPT cells) attenuates cisplatin-induced epithelial cell injury by eliminating mtROS and restoring mitochondrial homeostasis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: tubular epithelial cell
Concentration: 10, 20, 30, 40, 50, and 100 μM
Incubation Time: 2 hours
Result: Increased the levels of NRF2, SLC7A11, and GPX4 in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: TKPT cells
Concentration: 40 μM
Incubation Time: 2 hours
Result: Increased the levels of OM Porins, IMS Cyt c, IM CVa, IM Core 1, and Matrix CypD in a dose-dependent manner.
In Vivo

84-B10 (5-15 mg/kg; i.p.) alleviates cisplatin-induced acute kidney injury in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice with acute kidney injury[1]
Dosage: 5, 10, and 15 mg/kg
Administration: intraperitoneal injection
Result: Decreased the sCr and BUN levels of cisplatin-exposed mice.
Attenuated renal tubules morphological abnormalities in a dose-dependent manner.
Decreased NGAL and KIM-1 levels in a dose-dependent manner.
Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1.
Molecular Weight

473.44

Formula

C25H22F3NO5
CAS No.
SMILES

O=C(O)CC(CC(NC1=CC(C(F)(F)F)=CC=C1OC2=CC=C(OC)C=C2)=O)C3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

84-B10698346-43-9Ferroptosis3-phenylglutaricmitochondrial damageoxidative stressacute kidney injuryInhibitorinhibitorinhibit

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