Search Result

Isoforms Recommended:	Trk

Results for "

trk

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Trk Receptor (55) Anaplastic lymphoma kinase (ALK) (2) Apoptosis (5) Autophagy (1) Bcr-Abl (1) c-Fms (1) c-Kit (1) c-Met/HGFR (3) CDK (1) Drug Metabolite (1) EGFR (1) FLT3 (3) Ligands for E3 Ligase (1) PDGFR (1) PROTAC Linkers (1) Reactive Oxygen Species (1) RET (1) ROS Kinase (3) VEGFR (2) Wnt (1)
By Research Areas:	Cancer (55) Infection (1) Inflammation/Immunology (3) Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Trk Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146115

TRK-IN-19	Trk Receptor	Cancer
TRK-IN-19 (Compound I-10 ) is a potent inhibitor of *TRK* (TRKA IC₅₀ = 1.1 nM, TRKA ^G595R IC₅₀ = 5.3 nM). TRK-IN-19 has the potential for the research of cancer diseases .

HY-161179

TRK-IN-27

Trk Receptor Cancer

TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth .

TRK-IN-27	Trk Receptor	Cancer
TRK-IN-27 (Compound 14q) is a potent *TRK* inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth .

HY-144321

Trk-IN-9	Trk Receptor	Cancer
Trk-IN-9 (Compound 12) is a potent inhibitor of *TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis* of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers .

HY-146519

TRK-IN-14	Trk Receptor	Cancer
TRK-IN-14 is a potent inhibitor of *TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-14 has the potential for the research of TRK*-related diseases (extracted from patent WO2012034091A1, compound X-47) .

HY-146522

TRK-IN-16	Trk Receptor	Cancer
TRK-IN-16 is a potent inhibitor of *TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-16 has the potential for the research of TRK*-related diseases (extracted from patent WO2012034091A1, compound X-21) .

HY-146518

TRK-IN-13	Trk Receptor	Cancer
TRK-IN-13 is a potent inhibitor of *TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-13 has the potential for the research of TRK*-related diseases (extracted from patent WO2012034091A1, compound X-24) .

HY-146521

TRK-IN-15	Trk Receptor	Cancer
TRK-IN-15 is a potent inhibitor of *TRK. Protein kinases play a critical role in the control of cell growth and differentiation and are responsible for the control of a wide variety of cellular signal transduction processes. TRK-IN-15 has the potential for the research of TRK*-related diseases (extracted from patent WO2012034091A1, compound X-55) .

HY-144451

TRK-IN-12	Trk Receptor	Cancer
TRK-IN-12 (Compound 9e) is a potent inhibitor of *TRK* (TRK ^G595R IC₅₀ = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC₅₀ = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC₅₀ = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line .

HY-144732

TRK/ALK-IN-1	Trk Receptor Anaplastic lymphoma kinase (ALK)	Cancer
TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of *TRK* and ALK. TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC₅₀ values of 2.2, 9.3 and 38 nM towards TRKA, ALK ^WT and ALK ^L1196M, respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases .

HY-146524

TRK-IN-18	Trk Receptor	Cancer
TRK-IN-18 is a potent inhibitor of *TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK*-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7) .

HY-146523

TRK-IN-17	Trk Receptor	Cancer
TRK-IN-17 is a potent inhibitor of *TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK*-IN-17 has the potential for the research of cancer diseases (extracted from patent WO2021148807A1, compound 3) .

HY-144424

Trk-IN-11	Trk Receptor	Cancer
Trk-IN-11 (Compound 14h) is a potent inhibitor of *TRK* (IC₅₀ = 1.4, 1.8 nM, against TrkA, TrkA ^G595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease .

HY-144423

Trk-IN-10	Trk Receptor	Cancer
Trk-IN-10 (Compound 14j) is a potent inhibitor of *TRK* (IC₅₀ = 0.86, 6.92 nM, against TrkA, TrkA ^G595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-10 (IC₅₀ = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity .

HY-150561

Trk-IN-20	Trk Receptor	Cancer
Trk-IN-20 is a kind of 3-vinylindazole derivatives. Trk-IN-20 suppresses *Trk* kinases functions by phosphorylation inhibition of TrkA/B/C with IC₅₀ values of 1.6 nM, 2.9 nM and 2.0 nM, respectively .

HY-160165

TRK-IN-25

Trk Receptor Cancer

TRK-IN-25 (compound 16) is a Trk inhibitor with antiproliferative activity against cancer cells. TRK-IN-25 can be used in cancer research .
HY-150258

TRK-IN-22

Trk Receptor Others

TRK-IN-22 (compound 11) is a TRK inhibitor. TRK-IN-22 (compound 11), a typical type I inhibitor, covers the ATP-binding pocket of TRKA .
HY-160166

TRK-IN-26

Trk Receptor Cancer

TRK-IN-26 (compound 12) is a TRK inhibitor with potential for cancer research .
HY-139891

Trk-IN-6

Trk Receptor Cancer

Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants (IC₅₀ = 0.2-0.7 nM).

TRK-IN-25	Trk Receptor	Cancer
TRK-IN-25 (compound 16) is a *Trk* inhibitor with antiproliferative activity against cancer cells. TRK-IN-25 can be used in cancer research .

TRK-IN-22	Trk Receptor	Others
TRK-IN-22 (compound 11) is a *TRK* inhibitor. TRK-IN-22 (compound 11), a typical type I inhibitor, covers the ATP-binding pocket of TRKA .

TRK-IN-26	Trk Receptor	Cancer
TRK-IN-26 (compound 12) is a *TRK* inhibitor with potential for cancer research .

Trk-IN-6	Trk Receptor	Cancer
Trk-IN-6 shows excellent in vitro potency on a panel of *TRK* mutants (IC₅₀ = 0.2-0.7 nM).

HY-163366

TRK-IN-28	Trk Receptor	Cancer
TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC₅₀ values of 0.55 nM, 25.1 nM and 5.4 nM against TRK ^WT, TRK ^G595R and TRK ^G667C, respectively. TRK-IN-2 shows antiproliferative activity with IC₅₀ values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA ^WT, Ba/F3-ETV6-TRKB ^WT, Ba/F3-LMNA-TRK ^G595R and Ba/F3-LMNA-TRKA ^G667C, respectively .

HY-12327

Trk-IN-1	Trk Receptor	Neurological Disease Cancer
Trk-IN-1 (example 9), a potent tropomyosin-related kinase (Trk) inhibitor, shows potency against TrkA (3.7 nM) and TrkB (94 nM), respectively .

HY-151945

TRK II-IN-1	Trk Receptor FLT3 VEGFR RET	Cancer
TRK II-IN-1 is a potent type II *TRK* inhibitor, with IC₅₀s of 3.3, 6.4, 4.3 and 9.4 nM, for TRKA/B/C and TRKA ^G667C, respectively. TRK II-IN-1 also inhibits FLT3, RET, and VEGFR2 with IC₅₀s of 1.3, 9.9, and 71.1 nM, respectively. TRK II-IN-1 can be used for the research of TRK driven cancers .

HY-143561

Trk-IN-8	Trk Receptor	Cancer
Trk-IN-8 is a potent *TRK* inhibitor with IC₅₀s of 0.42, 0.89 and 1.5 nM for TRKAa, TRKA(G595R) and TRKC(G623R), respectively (WO2021115401A1, compound 3) .

HY-149965

TRK-IN-23	Trk Receptor Apoptosis	Cancer
TRK-IN-23 (compound 24b) is a potent and orally active *TRK* inhibitor with IC₅₀ values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKA ^G595R, TRKA ^F589L, and TRKA ^G667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells .

HY-156086

TRK-IN-24	Trk Receptor	Cancer
TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA, TRKC, TRKA ^G595R, TRKA ^G667C and TRKA ^F589L IC₅₀s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1 ^G595R and BaF3-CD74-NTRK1 ^G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC₅₀ of 1.43-47.56 nM .

HY-143557

Trk-IN-7	Trk Receptor	Cancer
Trk-IN-7 (compound I-6) is a potent *TRK* inhibitor with IC₅₀s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC₅₀<15 nM) ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC₅₀=5-50 nM) .

HY-112436

PF-6683324 trk-IN-4	Trk Receptor	Neurological Disease
PF-6683324 (Trk-IN-4) is a potent *pan-Trk* inhibitor in cell-based assays with IC₅₀s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively . Anti-hyperalgesic effect .

HY-146807

*Type II TRK* inhibitor 1**	Trk Receptor	Cancer
Type II TRK inhibitor 1 is a potent *TRK* inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKA ^G667C and ETV6-TRKC ^G696C fusion proteins with IC₅₀s of 6 nM and 1.7 nM, respectively . Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100695

DDR-TRK-1

DDR-TRK-1 is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC₅₀ value of 9.4 nM. DDR-TRK-1 also inhibits TRK family.

*DDR-TRK-1*
DDR-TRK-1 is a selective Discoidin Domain Receptor 1 (DDR1) inhibitor, with an IC₅₀ value of 9.4 nM. DDR-TRK-1 also inhibits TRK family.

HY-163004

*Type II TRK* inhibitor 2**	Trk Receptor	Cancer
Type II TRK inhibitor 2 (compound 40l) is a selective type II *TRK* inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKA ^G595R and Ba/F3-TRKA ^G667C cell proliferation (IC₅₀: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers .

HY-146697

*IHMT-TRK-284*	Trk Receptor c-Fms PDGFR Bcr-Abl c-Kit Apoptosis	Cancer
IHMT-TRK-284 (Compound 34) is a potent, orally active *type II TRK* kinase inhibitor with IC₅₀ values of 10.5, 0.7, and 2.6 nM to TRKA, B*, and C respectively. IHMT-TRK*-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies .

HY-144069

*Pan-Trk-IN-3*	Trk Receptor Apoptosis	Cancer
Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan-Trk and their drug-resistant mutants with IC₅₀ values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA, TrkB, TrkC, TrkA ^G595R, TrkA ^G667C, TrkA ^G667S, TrkA ^F589L and TrkC ^G623R, respectively. Pan-Trk-IN-3 displays excellent antitumor activity and induces apoptosis .

HY-144028

Pan-Trk-IN-2

Trk Receptor Cancer

Compound cpd-1 is a small molecule Trks inhibitor with good antitumor activity .
HY-157542

CG428-NEG

Others Others

CG428-NEG is a TRK degrader negative control. CG428-NEG inhibits cell growth and reduce TPM3-TRKA levels .

*Pan-Trk-IN-2*	Trk Receptor	Cancer
Compound cpd-1 is a small molecule *Trks* inhibitor with good antitumor activity .

CG428-NEG	Others	Others
CG428-NEG is a TRK degrader negative control. CG428-NEG inhibits cell growth and reduce TPM3-TRKA levels .

HY-152292

Zidesamtinib NVL-520	ROS Kinase	Cancer
Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC₅₀s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and spares TRK inhibition. Zidesamtinib can be used for the research of cancer .

HY-137465

CG428	Trk Receptor	Cancer
CG428 is a potent and selective tropomyosin receptor kinase (TRK) degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 (TPM3)-TRKA fusion protein in KM12 colorectal carcinoma cells (DC₅₀ = 0.36 nM) and inhibits downstream PLCγ1phosphorylation (IC₅₀ = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (K_d = 1 nM, 28 nM and 4.2 nM, respectively). In addition, CG428 effectively inhibits KM12 cell growth (IC₅₀ = 2.9 nM) .

HY-B0791

Altiratinib 1 Publications Verification DCC-2701	VEGFR c-Met/HGFR FLT3 Trk Receptor	Cancer
Altiratinib (DCC-2701) is a multi-targeted kinase inhibitor with IC₅₀s of 2.7, 8, 9.2, 9.3, 0.85, 4.6, 0.83 nM for MET, TIE2, VEGFR2, FLT3, *Trk1, Trk2, and Trk3* respectively.

HY-46531

Thalidomide-5-NH2-CH2-COOH	Ligands for E3 Ligase	Inflammation/Immunology Cancer
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for researching one or more diseases (extracted from patent WO2021170109A1) .

HY-N6732

K-252a Maximum Cited Publications 13 Publications Verification SF2370; Antibiotic K 252a; Antibiotic SF 2370
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-122616

PF-06273340

Trk Receptor Inflammation/Immunology

PF-06273340 is a potent, selective, orally bioavailable and peripherally restricted pan Trk inhibitor .

PF-06273340	Trk Receptor	Inflammation/Immunology
PF-06273340 is a potent, selective, orally bioavailable and peripherally restricted pan *Trk* inhibitor .

HY-163208

VH 032 amide-alkylC9-amine hydrochloride (S,R,S)-AHPC-C9-NH2 hydrochloride	PROTAC Linkers	Others
VH 032 amide-alkylC9-amine hydrochloride (Linker 33) is *TRK* ligand conjugated to the degradation tag .

HY-147303

Sacibertinib	Trk Receptor EGFR	Cancer
Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC₅₀ value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity .

HY-102066

Utatrectinib AZD-7451	Trk Receptor	Cancer
Utatrectinib (AZD-7451) is a potent, selective and orally active *Trk* inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors .

HY-132229

LPM4870108	Trk Receptor	Cancer
LPM4870108 is a potent and orally active *pan-Trk* (WT and MT) inhibitor, with IC₅₀s of 0.2 nM, 2.4 nM, 3.5 nM and 2.3 nM for TrkC, TrkA, TrkA ^G595R and TrkA ^G667C*, respectively. LPM4870108 shows selectivity for Trk* over ALK (IC₅₀=182 nM). LPM4870108 exhibits anti-tumor activity .

HY-131706A

GNF-8625 monopyridin-N-piperazine hydrochloride	Trk Receptor	Cancer
GNF-8625 monopyridin-N-piperazine hydrochloride (TRKi-2), a TRK inhibitor, which is from the patent WO 2020038415 A1 .

HY-153745

Protein kinase inhibitor 5	Trk Receptor	Cancer
Protein kinase inhibitor 5 is a potent *TRK-A* inhibitor with an IC₅₀ value of 1.8 nM. Protein kinase inhibitor 5 inhibits cell viability .

HY-101977

Selitrectinib 3 Publications Verification LOXO-195	Trk Receptor	Cancer
Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor, with IC₅₀s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively .

HY-12866B

(R)-Larotrectinib (R)-LOXO-101; (R)-ARRY-470	Trk Receptor	Infection Inflammation/Immunology Cancer
(R)-Larotrectinib is a potent *TRK* inhibitor with an IC₅₀ value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases

HY-148811

Zurletrectinib ICP-723	c-Met/HGFR	Cancer
Zurletrectinib is a potent tyrosine kinase inhibitor. Zurletrectinib serves as an antineoplastic agent. Zurletrectinib can used for research of preventing TRK-mediated related diseases, such as tumors .

HY-153745A

Protein kinase inhibitor 5 sulfate hydrate	Trk Receptor	Cancer
Protein kinase inhibitor 5 sulfate hydrate is a potent *TRK-A* inhibitor with an IC₅₀ value of 1.8 nM. Protein kinase inhibitor 5 sulfate hydrate inhibits cell viability .

HY-153743

Protein kinase inhibitor 4	ROS Kinase Trk Receptor	Cancer
Protein kinase inhibitor 4 (Compound 3) is a protein kinase inhibitor that inhibits *TRK-A* and ROS1 (IC₅₀=3.0 nM and 104 nM respectively) .

Species:	Human (8) Rat (5) Mouse (5) Rabbit (1) Canine (4)
Tag:	His (15) Tag Free (1) Avi (2) Fc (7) Flag (2)
Source:	HEK293 (20) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72264

	TPM2 Protein, Human (His) AMCD1; TMSA; TMSB; TPM2; trk; Tropomyosin beta chain	Human	E. coli
	The TPM2 protein binds actin filaments in muscle and nonmuscle cells and centrally regulates calcium-dependent striated muscle contraction in vertebrates, particularly in concert with the troponin complex. In smooth muscle cells, TPM2 helps regulate contraction by interacting with calcium-binding proteins. TPM2 Protein, Human (His) is the recombinant human-derived TPM2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of TPM2 Protein, Human (His) is 271 a.a., with molecular weight of ~38 kDa.

HY-P7308

	TrkA Protein, Human (HEK293) rHutrkA; Ntrk1; MTC; trk	Human	HEK293
	TrkA Protein, Human (HEK293) is the high affinity catalytic receptor for the neurotrophin, nerve growth factor (NGF), and mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death.

HY-P73457

	TrkA Protein, Human (HEK293, His) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Human	HEK293
	Pentraxin 3/TSG-14 protein is a multifunctional protein that plays a role in immune response and inflammation. It is involved in the recognition and clearance of pathogens, as well as regulation of inflammatory processes. Dysregulation of Pentraxin 3/TSG-14 protein has been associated with various diseases, including cardiovascular disorders and infections. Targeting Pentraxin 3/TSG-14 protein may hold therapeutic potential in these conditions. TrkA Protein, Human (HEK293, His) is the recombinant human-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Human (HEK293, His) is 220 a.a., with molecular weight of 35-60 kDa.

HY-P73456

	TrkA Protein, Canine (HEK293, His) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Canine	HEK293
	TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, His) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Canine (HEK293, His) is 126 a.a., with molecular weight of 27-33 kDa.

HY-P73459

	TrkA Protein, Rat (HEK293, Fc) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Rat	HEK293
	The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkA Protein, Rat (HEK293, Fc) is 418 a.a., with molecular weight of 92-102 kDa.

HY-P73460

	TrkA Protein, Rat (HEK293, His) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Rat	HEK293
	The TrkA protein is a receptor tyrosine kinase that is critical in central and peripheral nervous system development, regulating neuronal proliferation, differentiation, and survival. As a high-affinity NGF receptor, TrkA undergoes homodimerization and autophosphorylation upon ligand binding, activating downstream effectors (SHC1, FRS2, SH2B1, SH2B2, PLCG1) cascade. TrkA Protein, Rat (HEK293, His) is the recombinant rat-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rat (HEK293, His) is 386 a.a., with molecular weight of ~70-95 kDa.

HY-P73577

	TrkA Protein, Rabbit (HEK293, His) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Rabbit	HEK293
	TrkA Protein, Rabbit (HEK293, His) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. TRKA (NTRK1) gene encodes the high affinity receptor for a neurotrophin nerve growth factor (NGF). It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also controls proliferation, differentiation and survival of many neuronal and non-neuronal cells. TrkA Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rabbit (HEK293, His) is 382 a.a., with molecular weight of ~43.4 kDa.

HY-P73578

	TrkA Protein, Canine (HEK293, Fc) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Canine	HEK293
	TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of TrkA Protein, Canine (HEK293, Fc) is 126 a.a., with molecular weight of 55-61 kDa.

HY-P76115

	TrkA Protein, Mouse (HEK293, Fc) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Mouse	HEK293
	TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkA Protein, Mouse (HEK293, Fc) is 420 a.a., with molecular weight of ~116 kDa.

HY-P76116

	TrkA Protein, Mouse (HEK293, His) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Mouse	HEK293
	TrkA protein is a key receptor tyrosine kinase that guides the development and maturation of the nervous system and affects neuronal proliferation, differentiation, and survival. TrkA serves as a high-affinity receptor for NGF (its primary ligand) and also responds to NTF3/neurotropin-3. TrkA Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkA protein, expressed by HEK293 , with C-His, C-8*His labeled tag. The total length of TrkA Protein, Mouse (HEK293, His) is 387 a.a., with molecular weight of ~55-125 kDa.

HY-P73458

	TrkA Protein, Human (HEK293, His-Fc) High affinity nerve growth factor receptor; trk-A; Ntrk1; MTC; trk	Human	HEK293
	TrkA protein is an important receptor tyrosine kinase that regulates the development of the central and peripheral nervous systems and affects the proliferation, differentiation, and survival of neurons. As a high-affinity receptor for NGF, TrkA is activated upon NGF binding through homodimerization and autophosphorylation. TrkA Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkA protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TrkA Protein, Human (HEK293, His-Fc) is 382 a.a., with molecular weight of 85-95 kDa.

HY-P702762

	NTRK1/TrkA-I Protein, Human (Biotinylated, sf9, Flag, Avi) High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; Ntrk-1; Ntrk1; Slow nerve growth factor receptor; p140-trkA; trk-A; trk; trka; trk1-transforming tyrosine kinase protein; trkAOncogene trk; trktrk1; tyrosine kinase receptor A	Human	Sf9 insect cells

HY-P73461

	TrkB Protein, Canine (HEK293, His) BDNF/NT-3 Growth Factors Receptor; trk-B; Ntrk2; trkB	Canine	HEK293
	TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, His) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Canine (HEK293, His) is 399 a.a., with molecular weight of ~60-78 kDa.

HY-P73574

	TrkB Protein, Rat (HEK293, His) BDNF/NT-3 Growth Factors Receptor; trk-B; Ntrk2; trkB	Rat	HEK293
	TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems. As a receptor for BDNF and NTF4, it regulates survival through NTF3. TrkB Protein, Rat (HEK293, His) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Rat (HEK293, His) is 398 a.a., with molecular weight of ~67 kDa.

HY-P73575

	TrkB Protein, Rat (HEK293, Fc) BDNF/NT-3 Growth Factors Receptor; trk-B; Ntrk2; trkB	Rat	HEK293
	TrkB is a key receptor tyrosine kinase that coordinates multiple neuronal processes in the central and peripheral nervous systems. As a receptor for BDNF and NTF4, it regulates survival through NTF3. TrkB Protein, Rat (HEK293, Fc) is the recombinant rat-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkB Protein, Rat (HEK293, Fc) is 429 a.a., with molecular weight of ~120 kDa.

HY-P73576

	TrkB Protein, Canine (HEK293, Fc) BDNF/NT-3 Growth Factors Receptor; trk-B; Ntrk2; trkB	Canine	HEK293
	TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TrkB Protein, Canine (HEK293, Fc) is 430 a.a., with molecular weight of ~71.2 kDa.

HY-P73462

	TrkB Protein, Human (HEK293, His-Fc) BDNF/NT-3 Growth Factors Receptor; trk-B; Ntrk2; trkB	Human	HEK293
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His-Fc) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-hFc, C-His, C-10*His labeled tag. The total length of TrkB Protein, Human (HEK293, His-Fc) is 399 a.a., with molecular weight of 95-130 kDa.

HY-P73574A

	TrkB Protein, Rat (HEK293, C-His) BDNF/NT-3 Growth Factors Receptor; trk-B; Ntrk2; trkB	Rat	HEK293
	TrkB, a pivotal receptor tyrosine kinase, orchestrates diverse neuronal processes in the central and peripheral nervous systems. Serving as a receptor for BDNF and NTF4, it modulates survival through NTF3. Upon ligand binding, TrkB undergoes activation, initiating downstream cascades. It recruits effectors like SHC1, FRS2, SH2B1, SH2B2, and PLCG1, regulating pathways for differentiation, growth, survival, and synaptic plasticity. TrkB's role in learning involves short-term synaptic function, long-term potentiation, and PLCG1-mediated suppression of anoikis. Additionally, it contributes to neurotrophin-dependent calcium signaling in glial cells. TrkB Protein, Rat (HEK293, C-His) is the recombinant rat-derived TrkB protein, expressed by HEK293, with C-6*His labeled tag. The total length of TrkB Protein, Rat (HEK293, C-His) is 398 a.a., with molecular weight of ~62-85 kDa.

HY-P73463

	TrkB Protein, Mouse (429a.a, HEK293, His) BDNF/NT-3 Growth Factors Receptor; trk-B; Ntrk2; trkB	Mouse	HEK293
	TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (429a.a, HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Mouse (429a.a, HEK293, His) is 429 a.a., with molecular weight of 75-85 kDa.

HY-P71386

	TrkC Protein, Mouse (HEK293, His) GP145-trkC; trkC; trk-C; Neurotrophic tyrosine kinase receptor type 3; trkC tyrosine kinase; NT-3 Growth Factor Receptor	Mouse	HEK293
	TrkC Protein, a receptor tyrosine kinase, is vital in nervous system and potential heart development. Upon binding its ligand NTF3/neurotrophin-3, TrkC undergoes autophosphorylation, activating key signaling pathways like phosphatidylinositol 3-kinase/AKT and MAPK. These pathways intricately govern cell survival and differentiation, underscoring TrkC's pivotal role in orchestrating fundamental processes during development. TrkC Protein, Mouse (HEK293, His) is the recombinant mouse-derived TrkC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TrkC Protein, Mouse (HEK293, His) is 398 a.a., with molecular weight of 80-110 kDa.

HY-P72436

	TrkB Protein, Mouse (398a.a, HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-trkB; trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; trkB Tyrosine Kinase; Ntrk2; trkB	Mouse	HEK293
	TrkB protein, also known as tropomyosin receptor kinase B, consists of a non-catalytic isoform. Unlike its catalytic isoform, the noncatalytic isoform of TrkB lacks intrinsic kinase activity. TrkB Protein, Mouse (398a.a, HEK293, His) is the recombinant mouse-derived TrkB protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkB Protein, Mouse (398a.a, HEK293, His) is 398 a.a., with molecular weight of 60-90 kDa.

HY-P70793

	TrkB Protein, Human (HEK293, His) BDNF/NT-3 Growth Factors Receptor; GP145-trkB; trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; trkB Tyrosine Kinase; Tropomyosin-Related Kinase B; Ntrk2; trkB	Human	HEK293
	The TrkB protein is a key receptor tyrosine kinase that plays a key role in central and peripheral nervous system development. It regulates neuronal survival, proliferation, migration, differentiation, synapse formation, and plasticity. TrkB Protein, Human (HEK293, His) is the recombinant human-derived TrkB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TrkB Protein, Human (HEK293, His) is 399 a.a., with molecular weight of 60-105 kDa.

HY-P702763

	NTRK2/TrkB Protein, Human (Biotinylated, sf9, Flag, Avi) Ntrk2; neurotrophic tyrosine kinase, receptor, type 2; BDNF/NT-3 growth factors receptor; trk-B; GP145-trkB/GP95-trkB; trkB tyrosine kinase; Neural receptor protein-tyrosine kinase (trkB); Tkrb; trkB; trkB1; RATtrkB1	Human	Sf9 insect cells

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