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Cat. No.: HY-161179

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TRK-IN-27

TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth.

For research use only. We do not sell to patients.

CAS No.: 3032924-03-8
Formula: C₂₆H₂₈Cl₂FN₅O₂
Molecular Weight:532.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TRK-IN-27 Chemical Structure

CAS No.: 3032924-03-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth^[1].

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KM12	IC₅₀	70.8 nM Compound: 14q	Antiproliferative activity against human KM12 cells harboring TPM3-NTRK1 incubated for 72 hrs by CCK8 cell counting assay Antiproliferative activity against human KM12 cells harboring TPM3-NTRK1 incubated for 72 hrs by CCK8 cell counting assay	[PMID: 38227770]

Chemical Information

CAS No. 3032924-03-8
Molecular Weight 532.44
Formula C₂₆H₂₈Cl₂FN₅O₂
SMILES

FC1=C(Cl)C([C@H](NC2=CNC(C(C(NC3=CC=C(CN4CCN(C)CC4)C=C3)=O)=C2)=O)C)=C(Cl)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu Z, et al. Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment. J Med Chem. 2024 Jan 25;67(2):1168-1183. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TRK-IN-27

All Trk Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TRK-IN-27 Related Classifications

HY-161179 Related Classifications