1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. PF-06733804

PF-06733804 

Cat. No.: HY-112434
Handling Instructions

PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

PF-06733804 Chemical Structure

PF-06733804 Chemical Structure

CAS No. : 1873373-33-1

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Description

PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

IC50 & Target[1]

TrkA

8.4 nM (IC50, in cell-based assays)

TrkB

6.2 nM (IC50, in cell-based assays)

TrkC

2.2 nM (IC50, in cell-based assays)

In Vitro

PF-06733804 (Compound 19) also inhibits hERG in the FP and PX assay with IC50s of 79 μM and 88 μM, respectively[1].

Molecular Weight

474.38

Formula

C₂₀H₁₉F₅N₄O₄

CAS No.

1873373-33-1

SMILES

NC1=C(O[[email protected]@H]2C(F)(F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C2)C=C(C(NC)=O)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PF-06733804PF06733804PF 06733804Trk ReceptorTropomyosin related kinase receptorInhibitorinhibitorinhibit

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