1873373-33-1
1873373-33-1
Chemical Structure
PF-06733804
- CAS No.: 1873373-33-1
- Formula:C20H19F5N4O4
- Molecular Weight:474.38
IUPAC Name: (S)-6-amino-5-((4,4-difluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)pyrrolidin-3-yl)oxy)-N-methylnicotinamide
InChIKey: FTAFQADCGCSJAH-HNNXBMFYSA-N
SMILES: NC1=C(O[C@@H]2C(F)(F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C2)C=C(C(NC)=O)C=N1
Biological Activity: PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
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PF-06733804 | PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect. | |||||||||||||||||||||
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References
Keywords
