TRK/ALK-IN-1
TRK/ALK-IN-1 (compound 21) is a potent and dual inhibitor of TRK and ALK. TRK/ALK-IN-1 in the enzymatic assays is in good accordance with anti-proliferative activity with IC50 values of 2.2, 9.3 and 38 nM towards TRKA, ALKWT and ALKL1196M, respectively. TRK/ALK-IN-1 has the potential for the research of cancer diseases.
For research use only. We do not sell to patients.
- CAS No.: 3052405-64-5
- Formula: C31H35ClF2N8O2S
- Molecular Weight:657.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
TrkA |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 21
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Antiproliferative activity against EGFR-positive human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against EGFR-positive human A549 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34534734] |
| KARPAS-299 | IC50 |
0.072 μM
Compound: 21
|
Antiproliferative activity against NPM-ALK addicted human KARPAS-299 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against NPM-ALK addicted human KARPAS-299 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 34534734] |
| KM12 | IC50 |
0.086 μM
Compound: 21
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Antiproliferative activity against TPM3-NTRK1-addicted human KM12 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against TPM3-NTRK1-addicted human KM12 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 34534734] |
| NCI-H2228 | IC50 |
0.141 μM
Compound: 21
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Antiproliferative activity against EML4-ALK addicted human H2228 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against EML4-ALK addicted human H2228 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34534734] |
Chemical Information
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CAS No. 3052405-64-5
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Molecular Weight 657.18
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Formula C31H35ClF2N8O2S
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SMILES
CN1CCN(CC1)C2=CC=C(C=C2C(N3CCSCC3)=O)NC([C@@H]4CCCN4C5=NC(NC6=CC(F)=CC(F)=C6)=NC=C5Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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