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  5. TrkA Protein, Rabbit (HEK293, His)

TrkA Protein, Rabbit (HEK293, His)

Cat. No.: HY-P73577
Handling Instructions

TrkA Protein, Rabbit (HEK293, His) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. TRKA (NTRK1) gene encodes the high affinity receptor for a neurotrophin nerve growth factor (NGF). It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also controls proliferation, differentiation and survival of many neuronal and non-neuronal cells. TrkA Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rabbit (HEK293, His) is 382 a.a., with molecular weight of ~43.4 kDa.

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Description

TrkA Protein, Rabbit (HEK293, His) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. TRKA (NTRK1) gene encodes the high affinity receptor for a neurotrophin nerve growth factor (NGF). It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also controls proliferation, differentiation and survival of many neuronal and non-neuronal cells[1][2]. TrkA Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived TrkA protein, expressed by HEK293 , with C-His labeled tag. The total length of TrkA Protein, Rabbit (HEK293, His) is 382 a.a., with molecular weight of ~43.4 kDa.

Background

TRKA with the highly similar receptors TRKB and TRKC belongs to the group of tyrosine kinase receptors. TRKB binds neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) while TRKC is the predominant receptor for neurotrophin NT-3, although TRKA and TRKB can also be activated by NT-3. Signaling initiated by the NGF-TRKA complex is crucial for the development of pain-mediating sensory neurons, postganglionic sympathetic neurons and basal forebrain cholinergic neurons[1].
TRKA (also known as NTRK1) gene is a target of alternative splicing which can result in several different protein isoforms. TRKA is encoded by the NTRK1 gene located on chromosome 1q21-q22. Presently, three human isoforms (TRKAI, TRKAII and TRKAIII) and two rat isoforms (TRKA L0 and TRKA L1) have been described. Human TRKA gene is overlapped by two genes and spans 67 kb. TrkA genes in rat and mouse appear to be considerably shorter, are not overlapped by other genes. Human TRKA gene is located on chromosome 1 and has been described to span 23 kb. Seventeen exons, that are relatively well conserved in rat and mouse as compared to human TRKA gene, [the basic local alignment search tool (BLAST) algorithm gives 85 % of similarity in both cases] have been characterized[1][2].

Species

Rabbit

Source

HEK293

Tag

C-His

Accession

XP_008262512 (A33-E414)

Gene ID
Molecular Construction
N-term
TrkA (A33-E414)
Accession # XP_008262512
His
C-term
Synonyms
High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK
Molecular Weight

Approximately 43.4 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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TrkA Protein, Rabbit (HEK293, His)
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HY-P73577
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