Type II TRK inhibitor 2
Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cell proliferation (IC50: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers.
For research use only. We do not sell to patients.
- Formula: C30H27F2N9O
- Molecular Weight:567.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
1.4 nM
Compound: 40l
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Antiproliferative activity against mouse BaF3 cells harboring TRKA G667C mutant assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring TRKA G667C mutant assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
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[PMID: 38029466] |
| BaF3 | IC50 |
41.5 nM
Compound: 40l
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Antiproliferative activity against mouse BaF3 cells harboring TRKA G595R mutant assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring TRKA G595R mutant assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
|
[PMID: 38029466] |
| BaF3 | IC50 |
4827.5 nM
Compound: 40l
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Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
|
[PMID: 38029466] |
| KM12 | IC50 |
4.1 nM
Compound: 40l
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Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human KM12 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
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[PMID: 38029466] |
| MCF7 | IC50 |
>20000 nM
Compound: 40l
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
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[PMID: 38029466] |
Chemical Information
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Molecular Weight 567.59
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Formula C30H27F2N9O
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SMILES
O=C(NC1=CC(C(C)(C)C)=NN1C2=CC(F)=CC(F)=C2)NC3=CC=CC(NC4=CC5=C(C=C4)C(C6=CNN=C6)=NN5)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Type II TRK inhibitor 2 Related Classifications
HY-163004 Related Classifications
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