GNF-8625 monopyridin-N-piperazine hydrochloride

Cat. No.: HY-131706A Purity: 99.74%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GNF-8625 monopyridin-N-piperazine hydrochloride (TRKi-2), a TRK inhibitor, which is from the patent WO 2020038415 A1.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

GNF-8625 monopyridin-N-piperazine hydrochloride 화학구조

CAS No. : 2412055-62-8

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE GNF-8625 monopyridin-N-piperazine hydrochloride

•bioRxiv. 2025 Jun 24:2025.06.18.660465. [Abstract]

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Trk Receptor Isoform Specific Products:

View All Isoforms

TrkA TrkB TrkC Trk

Biological Activity
순도&문서
References
고객리뷰

제품 설명

GNF-8625 monopyridin-N-piperazine hydrochloride (TRKi-2), a TRK inhibitor, which is from the patent WO 2020038415 A1^[1].

분자량

479.98

화학식

C₂₅H₂₇ClFN₇

CAS No.

2412055-62-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=CC([C@@H]2N(C3=NN4C(C=C3)=NC=C4C5=NC(N6CCNCC6)=CC=C5)CCC2)=CC=C1.[H]Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 6.67 mg/mL (13.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0834 mL	10.4171 mL	20.8342 mL
5 mM	0.4167 mL	2.0834 mL	4.1668 mL
10 mM	0.2083 mL	1.0417 mL	2.0834 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.74%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (256 KB) HNMR (132 KB) RP-HPLC (242 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. By Liu, Jing, et al. Preparation of tropomyosin receptor kinase degradation compounds and methods of use. WO 2020038415 A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0834 mL	10.4171 mL	20.8342 mL	52.0855 mL
	5 mM	0.4167 mL	2.0834 mL	4.1668 mL	10.4171 mL
	10 mM	0.2083 mL	1.0417 mL	2.0834 mL	5.2086 mL