1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. CH7057288

CH7057288 

Cat. No.: HY-107362 Purity: 98.52%
Handling Instructions

CH7057288 is a potent and selective TRK inhibitor.

For research use only. We do not sell to patients.

CH7057288 Chemical Structure

CH7057288 Chemical Structure

CAS No. : 2095616-82-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 439 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

CH7057288 is a potent and selective TRK inhibitor.

IC50 & Target[1]

TRK

 

In Vitro

CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer[1].

Molecular Weight

569.67

Formula

C₃₂H₃₁N₃O₅S

CAS No.

2095616-82-1

SMILES

O=C1C2=C(OC3=CC(C#CC4=CC(C(NC(C)(C)C)=O)=CC(C)=N4)=CC=C23)C(C)(C)C5=CC(NS(C)(=O)=O)=CC=C15

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (59.68 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7554 mL 8.7770 mL 17.5540 mL
5 mM 0.3511 mL 1.7554 mL 3.5108 mL
10 mM 0.1755 mL 0.8777 mL 1.7554 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (4.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.52%

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Product Name:
CH7057288
Cat. No.:
HY-107362
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