1. Protein Tyrosine Kinase/RTK
  2. Trk Receptor

CH7057288 

Cat. No.: HY-107362 Purity: 98.34%
Handling Instructions

CH7057288 is a potent and selective TRK inhibitor.

For research use only. We do not sell to patients.

CH7057288 Chemical Structure

CH7057288 Chemical Structure

CAS No. : 2095616-82-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 439 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CH7057288 is a potent and selective TRK inhibitor.

IC50 & Target[1]

TRK

 

In Vitro

CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7554 mL 8.7770 mL 17.5540 mL
5 mM 0.3511 mL 1.7554 mL 3.5108 mL
10 mM 0.1755 mL 0.8777 mL 1.7554 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

569.67

Formula

C₃₂H₃₁N₃O₅S

CAS No.

2095616-82-1

SMILES

O=C1C2=C(OC3=CC(C#CC4=CC(C(NC(C)(C)C)=O)=CC(C)=N4)=CC=C23)C(C)(C)C5=CC(NS(C)(=O)=O)=CC=C15

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CH7057288
Cat. No.:
HY-107362
Quantity:

CH7057288

Cat. No.: HY-107362