2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Tavilermide

Tavilermide  (Synonyms: MIM-D3)

Cat. No.: HY-17622 Purity: 98.98%
COA Handling Instructions

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

For research use only. We do not sell to patients.

Tavilermide Chemical Structure

Tavilermide Chemical Structure

CAS No. : 263251-78-1

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1 mg USD 180 In-stock
5 mg USD 540 In-stock
10 mg USD 900 In-stock
50 mg USD 2700 In-stock
100 mg USD 3960 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Tavilermide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

IC50 & Target

TrkA[1]
In Vitro

Tavilermide (MIM-D3) is a tyrosine kinase TrkA receptor agonist, which can be used to treat dry eye.Tavilermide is a proteolytically stable, cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist. Tavilermide demonstrates activities similar to NGF (but does not bind to the p75NTR receptor) and can potentiate the effects of suboptimal concentrations of NGF[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tavilermide Related Antibodies
Clinical Trial
Molecular Weight

580.54

Appearance

Solid

Formula

C24H32N6O11
CAS No.
SMILES

O=C(O)CC[C@H](N1)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(O)=O)=O)CCOC2=CC=C([N+]([O-])=O)C=C2C1=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

NH4OH : 50 mg/mL (86.13 mM; ultrasonic and adjust pH to 10 with NH4OH)

H2O : 2 mg/mL (3.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7225 mL 8.6127 mL 17.2253 mL
5 mM 0.3445 mL 1.7225 mL 3.4451 mL
10 mM 0.1723 mL 0.8613 mL 1.7225 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 25 mg/mL (43.06 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 10 mg/mL (17.23 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  PBS

    Solubility: 4.17 mg/mL (7.18 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Tavilermide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tavilermide263251-78-1MIM-D3Trk ReceptorTropomyosin related kinase receptorInhibitorinhibitorinhibit

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