1. Protein Tyrosine Kinase/RTK
  2. Trk Receptor

Tavilermide (Synonyms: MIM-D3)

Cat. No.: HY-17622 Purity: >98.0%
Handling Instructions

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

For research use only. We do not sell to patients.
Tavilermide Chemical Structure

Tavilermide Chemical Structure

CAS No. : 263251-78-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 690 In-stock
1 mg USD 180 In-stock
5 mg USD 540 In-stock
10 mg USD 900 In-stock
50 mg USD 2700 In-stock
100 mg USD 3960 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

IC50 & Target

TrkA[1]

In Vitro

Tavilermide (MIM-D3) is a tyrosine kinase TrkA receptor agonist, which can be used to treat dry eye.Tavilermide is a proteolytically stable, cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist. Tavilermide demonstrates activities similar to NGF (but does not bind to the p75NTR receptor) and can potentiate the effects of suboptimal concentrations of NGF[1].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7225 mL 8.6127 mL 17.2253 mL
5 mM 0.3445 mL 1.7225 mL 3.4451 mL
10 mM 0.1723 mL 0.8613 mL 1.7225 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

580.54

Formula

C₂₄H₃₂N₆O₁₁

CAS No.

263251-78-1

SMILES

O=C(O)CC[[email protected]](N1)C(N[[email protected]@H](CCCCN)C(N[[email protected]](C(NCC(O)=O)=O)CCOC2=CC=C([N+]([O-])=O)C=C2C1=O)=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Tavilermide
Cat. No.:
HY-17622
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