CH7057288 (Standard)
CH7057288 (Standard) is the analytical standard of CH7057288 (HY-107362). This product is intended for research and analytical applications. CH7057288 is a potent and selective TRK inhibitor. CH7057288 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2095616-82-1
- Formula: C32H31N3O5S
- Molecular Weight:569.67
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13491
GNF-5837Trk Receptor Inhibitor -
HY-12497
ANA-12TrkB Antagonist -
HY-101977
SelitrectinibTRK Kinase Inhibitor -
HY-12866
LarotrectinibTRK Inhibitor -
HY-18314
GW 441756TrkA Inhibitor -
HY-107362
CH7057288TRK Inhibitor -
HY-12866A
Larotrectinib sulfateTRK Inhibitor -
HY-100673
LM22A-4TrkB Agonist -
HY-17622
TavilermideTrk Receptor Agonist -
HY-122616
PF-06273340pan-Trk Inhibitor -
HY-15590
AZ-23Trk Receptor Inhibitor -
HY-104047
LM22B-10TrkB/TrkC Activator
Biological Activity
Description
IC50 & Target
TRK [1]
Chemical Information
-
CAS No. 2095616-82-1
-
Molecular Weight 569.67
-
Formula C32H31N3O5S
-
SMILES
O=C1C2=C(OC3=CC(C#CC4=CC(C(NC(C)(C)C)=O)=CC(C)=N4)=CC=C23)C(C)(C)C5=CC(NS(C)(=O)=O)=CC=C15
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
The EdU incorporation assay measures DNA synthesis by adding the thymidine analog 5-ethynyl-2′-deoxyuridine to cells or tissues, where it is incorporated into newly synthesized DNA during S phase. Incorporated EdU is detected by copper-catalyzed azide-alkyne cycloaddition, in which a fluorescent azide covalently reacts with the ethynyl group on EdU, allowing S-phase cells to be detected by fluorescence microscopy, flow cytometry, or high-content imaging. EdU detection does not require DNA denaturation or anti-BrdU antibody access, which preserves sample structure and improves compatibility with immunostaining and multiparameter cytometry compared with BrdU-based detection. EdU can be cytotoxic in a cell-type- and exposure-dependent manner, so pulse duration, concentration, and continuous-labeling designs should be validated for each cell type.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CH7057288 (Standard) Related Classifications
HY-107362R Related Classifications
Powered by Bioz