1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. Trk-IN-4

Trk-IN-4 (Synonyms: PF-6683324 isomer)

Cat. No.: HY-112436
Handling Instructions

Trk-IN-4 (PF-6683324 isomer) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

Trk-IN-4 Chemical Structure

Trk-IN-4 Chemical Structure

CAS No. : 1799788-94-5

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Description

Trk-IN-4 (PF-6683324 isomer) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

IC50 & Target[1]

TrkA

1.9 nM (IC50, in cell-based assays)

TrkB

2.6 nM (IC50, in cell-based assays)

TrkC

1.1 nM (IC50, in cell-based assays)

In Vitro

Trk-IN-4 (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1].

Molecular Weight

521.46

Formula

C₂₄H₂₃F₄N₅O₄

CAS No.

1799788-94-5

SMILES

O=C(N)C1=C(O[[email protected]]2CCN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C[[email protected]]2F)N=CC(C4=CN(C)C=N4)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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