2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. PF-6683324

PF-6683324  (Synonyms: Trk-IN-4)

Cat. No.: HY-112436 Purity: 99.41%
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PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

PF-6683324 Chemical Structure

PF-6683324 Chemical Structure

CAS No. : 1799788-94-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 110 In-stock
Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 180 In-stock
25 mg USD 390 In-stock
50 mg USD 660 In-stock
100 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

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PF-6683324 Related Antibodies

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Description

PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

IC50 & Target[1]

TrkA

1.9 nM (IC50, in cell-based assays)

TrkB

2.6 nM (IC50, in cell-based assays)

TrkC

1.1 nM (IC50, in cell-based assays)

In Vitro

PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-6683324 Related Antibodies
Molecular Weight

521.46

Formula

C24H23F4N5O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N)C1=C(O[C@H]2CCN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C[C@H]2F)N=CC(C4=CN(C)C=N4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (191.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9177 mL 9.5885 mL 19.1769 mL
5 mM 0.3835 mL 1.9177 mL 3.8354 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9177 mL 9.5885 mL 19.1769 mL 47.9423 mL
5 mM 0.3835 mL 1.9177 mL 3.8354 mL 9.5885 mL
10 mM 0.1918 mL 0.9588 mL 1.9177 mL 4.7942 mL
15 mM 0.1278 mL 0.6392 mL 1.2785 mL 3.1962 mL
20 mM 0.0959 mL 0.4794 mL 0.9588 mL 2.3971 mL
25 mM 0.0767 mL 0.3835 mL 0.7671 mL 1.9177 mL
30 mM 0.0639 mL 0.3196 mL 0.6392 mL 1.5981 mL
40 mM 0.0479 mL 0.2397 mL 0.4794 mL 1.1986 mL
50 mM 0.0384 mL 0.1918 mL 0.3835 mL 0.9588 mL
60 mM 0.0320 mL 0.1598 mL 0.3196 mL 0.7990 mL
80 mM 0.0240 mL 0.1199 mL 0.2397 mL 0.5993 mL
100 mM 0.0192 mL 0.0959 mL 0.1918 mL 0.4794 mL
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PF-6683324 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-66833241799788-94-5Trk-IN-4PF6683324PF 6683324Trk ReceptorTropomyosin related kinase receptorInhibitorinhibitorinhibit

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