Trk-IN-6

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.2 nM Compound: 8	Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKA assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKA assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34668694]
BaF3	IC₅₀	0.2 nM Compound: 8	Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKC assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKC assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34668694]
BaF3	IC₅₀	0.2 nM Compound: 8	Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA F589L mutant assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA F589L mutant assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34668694]
BaF3	IC₅₀	0.3 nM Compound: 8	Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKB assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKB assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34668694]
BaF3	IC₅₀	1.6 nM Compound: 8	Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA G595R mutant assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA G595R mutant assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34668694]
BaF3	IC₅₀	10.9 nM Compound: 8	Antiproliferative activity aganist mouse BAF3 cells transfected with LMNA-TRKA G667C mutant assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity aganist mouse BAF3 cells transfected with LMNA-TRKA G667C mutant assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34668694]

Cell Line

Type

Value

Description

References

BaF3

IC₅₀

0.2 nM

Compound: 8

Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKA assessed as cell viability incubated for 72 hrs by CCK8 assay

[PMID: 34668694]

BaF3

IC₅₀

0.2 nM

Compound: 8

Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKC assessed as cell viability incubated for 72 hrs by CCK8 assay

[PMID: 34668694]

BaF3

IC₅₀

0.2 nM

Compound: 8

Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA F589L mutant assessed as cell viability incubated for 72 hrs by CCK8 assay

[PMID: 34668694]

BaF3

IC₅₀

0.3 nM

Compound: 8

Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKB assessed as cell viability incubated for 72 hrs by CCK8 assay

[PMID: 34668694]

BaF3

IC₅₀

1.6 nM

Compound: 8

Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA G595R mutant assessed as cell viability incubated for 72 hrs by CCK8 assay

[PMID: 34668694]

BaF3

IC₅₀

10.9 nM

Compound: 8

Antiproliferative activity aganist mouse BAF3 cells transfected with LMNA-TRKA G667C mutant assessed as cell viability incubated for 72 hrs by CCK8 assay

[PMID: 34668694]

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