Trk-IN-7
Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC50s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC50<15 nM) ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50=5-50 nM).
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- No. CAS: 2383011-61-6
- Fòrmula: C18H17FN6O2
- Peso molecular:368.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
TrkA <25 nM (IC50) |
TrkB <5 nM (IC50) |
TrkC <25 nM (IC50) |
Chemical Information
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No. CAS 2383011-61-6
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Peso molecular 368.36
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Fòrmula C18H17FN6O2
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SMILES
FC1=CN=C(O[C@H]2C[C@H](C2)NC3=O)C([C@H](NC4=NC5=C3C=NN5C=C4)C)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trk-IN-7 Related Classifications
HY-143557 Related Classifications
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