2383011-61-6
Chemical Structure
Trk-IN-7
- CAS 番号: 2383011-61-6
- Formula:C18H17FN6O2
- Molecular Weight:368.36
IUPAC Name: (31S,33S,63E,64E,8R)-15-fluoro-8-methyl-2-oxa-4,7-diaza-6(3,5)-pyrazolo[1,5-a]pyrimidina-1(2,3)-pyridina-3(1,3)-cyclobutanacyclooctaphan-5-one
InChIKey: MPTHHGRJSLVPSX-JLLWLGSASA-N
SMILES: FC1=CN=C(O[C@H]2C[C@H](C2)NC3=O)C([C@H](NC4=NC5=C3C=NN5C=C4)C)=C1
Biological Activity: Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC50s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC50<15 nM) ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50=5-50 nM)[1].
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Trk-IN-7 | Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC50s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC50<15 nM) ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50=5-50 nM). | |||||||||||||||||||||
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Keywords
