1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. PF-06737007

PF-06737007 

Cat. No.: HY-112437
Handling Instructions

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

PF-06737007 Chemical Structure

PF-06737007 Chemical Structure

CAS No. : 1863905-38-7

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Description

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

IC50 & Target

TrkA

7.7 nM (IC50, in cell-based assays)

TrkB

15 nM (IC50, in cell-based assays)

TrkC

3.9 nM (IC50, in cell-based assays)

In Vitro

PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM[1].

Molecular Weight

528.49

Formula

C₂₅H₂₈F₄N₂O₆

CAS No.

1863905-38-7

SMILES

O=C(N)C1=CC=C(OCC(C)(O)C)C=C1O[[email protected]@H]2[[email protected]](F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PF-06737007
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