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Cat. No.: HY-147303

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Sacibertinib

Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC₅₀ value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity.

For research use only. We do not sell to patients.

CAS No.: 1351941-69-9
Formula: C₃₂H₃₁ClN₆O₄
Molecular Weight:599.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Sacibertinib Chemical Structure

CAS No.: 1351941-69-9

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC₅₀ value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity^[1].

IC₅₀ & Target^[1]

EGFR-TK phosphorylation

110 nM (EC₅₀)

HER2

244 nM (EC₅₀)

All Trk Receptor Isoforms :

All EGFR Isoforms :

In Vitro

Sacibertinib has inhibitory activity against Sk-Br-3, SW620 cells with GI₅₀s of 3.8 nM and 1.78 μM, and against CCRF-CEM/T, Fadu, BxPc-3 and AsPC-1 with IC₅₀s of 5.6 μM, 101 nM, 337 nM and 1 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1351941-69-9
Molecular Weight 599.08
Formula C₃₂H₃₁ClN₆O₄
SMILES

CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)OCC3=CC=CC=N3)=C(C#N)C=N4)=C4C=C1O[C@H]5CCOC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hesheng Zhang, et al. Cyanoquinoline derivatives. CA2802130A1 (Example 138)

[2]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Sacibertinib

All Trk Receptor Isoforms

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sacibertinib Related Classifications

HY-147303 Related Classifications