1. Neuronal Signaling JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. Trk Receptor EGFR
  3. Sacibertinib

Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity.

For research use only. We do not sell to patients.

Sacibertinib Chemical Structure

Sacibertinib Chemical Structure

CAS No. : 1351941-69-9

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Description

Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].

IC50 & Target[1]

EGFR-TK phosphorylation

110 nM (EC50)

HER2

244 nM (EC50)

In Vitro

Sacibertinib has inhibitory activity against Sk-Br-3, SW620 cells with GI50s of 3.8 nM and 1.78 μM, and against CCRF-CEM/T, Fadu, BxPc-3 and AsPC-1 with IC50s of 5.6 μM, 101 nM, 337 nM and 1 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

599.08

Formula

C32H31ClN6O4

CAS No.
SMILES

CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)OCC3=CC=CC=N3)=C(C#N)C=N4)=C4C=C1O[C@H]5CCOC5)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sacibertinib
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HY-147303
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