1351941-69-9
1351941-69-9
Chemical Structure
Sacibertinib
- CAS No.: 1351941-69-9
- Formula:C32H31ClN6O4
- Molecular Weight:599.08
IUPAC Name: (S,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-((tetrahydrofuran-3-yl)oxy)quinolin-6-yl)-4-(dimethylamino)but-2-enamide
InChIKey: ZGYIXVSQHOKQRZ-COIATFDQSA-N
SMILES: CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)OCC3=CC=CC=N3)=C(C#N)C=N4)=C4C=C1O[C@H]5CCOC5)=O
Biological Activity: Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].
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Sacibertinib | Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity. | |||||||||||||||||||||
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