1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. Trk-IN-10

Trk-IN-10 

Cat. No.: HY-144423
Handling Instructions

Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity.

For research use only. We do not sell to patients.

Trk-IN-10 Chemical Structure

Trk-IN-10 Chemical Structure

CAS No. : 2700265-61-6

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Description

Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity[1].

Molecular Weight

397.40

Formula

C20H20FN5O3

CAS No.
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Trk-IN-10
Cat. No.:
HY-144423
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