2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Trk-IN-11

Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease.

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Trk-IN-11 Chemical Structure

Trk-IN-11 Chemical Structure

CAS No. : 2700265-62-7

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Trk-IN-11 Related Antibodies

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Description

Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease[1].

IC50 & Target

TrkA

 

Molecular Weight

411.43

Formula

C21H22FN5O3
CAS No.
SMILES

C[C@H]1N2C3=NC4=C(C(NC(C)(COC5=CC(F)=CC=C5C2)C)=O)C=NN4C=C3OC1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trk-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trk-IN-112700265-62-7Trk ReceptorTropomyosin related kinase receptorTRKTrkARTKdrug targetsolid tumorscancerInhibitorinhibitorinhibit

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