2700265-62-7
Chemical Structure
Trk-IN-11
- CAS No.: 2700265-62-7
- Formula:C21H22FN5O3
- Molecular Weight:411.43
IUPAC Name: (R,14aE,15aE)-34-fluoro-13,6,6-trimethyl-13,14-dihydro-12H-4-oxa-7-aza-1(4,6)-pyrazolo[1',5':1,2]pyrimido[5,4-b][1,4]oxazina-3(1,2)-benzenacyclooctaphan-8-one
InChIKey: HVIJVFYUUAELBN-GFCCVEGCSA-N
SMILES: C[C@H]1N2C3=NC4=C(C(NC(C)(COC5=CC(F)=CC=C5C2)C)=O)C=NN4C=C3OC1
Biological Activity: Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease[1].
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Trk-IN-11 | Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease. | |||||||||||||||||||||
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Keywords
