1D228
1D228 is a c-Met/TRK inhibitor with antitumor activity. 1D228 inhibits cyclin D1 to induce G0/G1 arrest and inhibit cancer cell proliferation and migration. 1D228 can be used in the study of gastric, liver and vascular tumors.
For research use only. We do not sell to patients.
- CAS No.: 2925447-16-9
- Formula: C30H29DN6O2
- Molecular Weight:507.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MHCC97H | IC50 |
4.3 nM
Compound: 84; 1D228
|
Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 38733884] |
| MKN-45 | IC50 |
1 nM
Compound: 84; 1D228
|
Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 38733884] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2925447-16-9
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Molecular Weight 507.60
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Formula C30H29DN6O2
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SMILES
[2H][C@@](C1=CC=CC(C2=NC=C(C=N2)OCC3CCN(CC3)C)=C1)(N4N=C(C=CC4=O)C5=CC=CC(C#N)=C5)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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