country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-157148

Copy Link Print Information

1D228

1D228 is a c-Met/TRK inhibitor with antitumor activity. 1D228 inhibits cyclin D1 to induce G0/G1 arrest and inhibit cancer cell proliferation and migration. 1D228 can be used in the study of gastric, liver and vascular tumors.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2925447-16-9
화학식: C₃₀H₂₉DN₆O₂
분자량:507.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

1D228 Chemical Structure

CAS No.: 2925447-16-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MHCC97H	IC₅₀	4.3 nM Compound: 84; 1D228	Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MHCC97H cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 38733884]
MKN-45	IC₅₀	1 nM Compound: 84; 1D228	Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human MKN-45 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 38733884]

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2925447-16-9
분자량 507.60
화학식 C₃₀H₂₉DN₆O₂
SMILES

[2H][C@@](C1=CC=CC(C2=NC=C(C=N2)OCC3CCN(CC3)C)=C1)(N4N=C(C=CC4=O)C5=CC=CC(C#N)=C5)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. An B, et al. A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation. Cell Death Dis. 2023 Nov 9;14(11):728. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기