2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Trk-IN-9

Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers.

For research use only. We do not sell to patients.

Trk-IN-9 Chemical Structure

Trk-IN-9 Chemical Structure

CAS No. : 2758623-12-8

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Trk-IN-9 Related Antibodies

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Description

Trk-IN-9 (Compound 12) is a potent inhibitor of TRK. Trk-IN-9 inhibits the proliferation of Km-12 cell lines. Trk-IN-9 induces the apoptosis of Km-12 cells in a concentration-dependent manner. Trk-IN-9 inhibits the phosphorylation of TRK to block downstream pathways. Trk-IN-9 has the potential for the research of NTRK-fusion cancers[1].

Molecular Weight

454.93

Formula

C23H24ClFN6O
CAS No.
SMILES

FC1=CC=CC(CNC2=NC(NC3=CC(C(N[C@@H]4CCCNC4)=O)=CC=C3)=NC=C2Cl)=C1
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trk-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trk-IN-92758623-12-8Trk ReceptorTropomyosin related kinase receptorTRKproliferationapoptosisphosphorylationNTRK-fusion cancersInhibitorinhibitorinhibit

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