α-Amyrin  (Synonyms: α-アミリン)

α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin shows anti-bacterial and anti-inflammation activity. α-Amyrin can reduce blood glucose level. α-Amyrin can be used for the researches of cancer, infection, inflammation, metabolic disease and neurological disease, such as breast cancer, Streptococcus oralis infection, skin inflammation and diabetes^{[1][2][3][4][5][6][7]}.

α-Amyrin (10 μM, 24 h) induces AMPK and PPARδ/ γ-mediated GLUT4 translocation in C2C12 myoblasts^[1].
α-Amyrin (acetate) (2.5-10 μg/mL, 0-72 h) inhibits proliferation and colony formation in MDA-MB-231 cells^[6].
α-Amyrin (acetate) (5-10 μg/mL, 24 h) induces apoptosis and increases caspase-3 activity in MDA-MB-231 cells^[6].
α-Amyrin (acetate) (10 μg/mL, 24 h) promotes the cleavage of Poly polymerase, increased E-cadherin, and inhibits vimentin and phosphorylated extracellular signal-regulated activation in MDA-MB-231 cells^[6].
α-Amyrin (10-1000 μg/mL, 24 h) reduces percentage of viability of Streptococcus salivarius, Streptococcus sanguinis and Streptococcus oralis^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Amyrin (50-200 mg/kg, p.o., once daily for 42 days) can reduce the survival rate of rats with metabolic syndrome induced by high fructose diet^[2].
α-Amyrin (2-4 mg/kg, p.o.) improves cognitive dysfunction caused by low cholinergic neurotransmission in mice by activating ERK and GSK-3β signaling pathways^[3].
α-Amyrin (acetate) (50 mg/kg, p.o., daily for 1-10 days) reduces the blood glucose level in diabetic rats^[4].
α-Amyrin (0.1-1.0 mg/ear, topical application) inhibits inflammation in 12-O-tetradecanoylphorbol-acetate (TPA)-induced skin inflammation of mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

426.72

C₃₀H₅₀O

638-95-9

Solid

White to off-white

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@H]([C@@H]4C)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC2)C)C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Giacoman-Martínez A, et al. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Can J Physiol Pharmacol. 2021 Sep;99(9):935-942.  [Content Brief]

  [2]. Prabhakar P, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Appl Physiol Nutr Metab. 2017 Jan;42(1):23-32.  [Content Brief]

  [3]. Park SJ, et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol Pharm Bull. 2014;37(7):1207-13.  [Content Brief]

  [4]. Singh AB, et al. Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice. Nat Prod Res. 2009;23(9):876-82.  [Content Brief]

  [5]. Medeiros R, et al. Mechanisms underlying the inhibitory actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol. 2007 Mar 22;559(2-3):227-35.  [Content Brief]

  [6]. Kevine Kamga Silihe, Purification of α-amyrin-acetate and phenylpropanoïd compounds from Ficus umbellata Vahl (Moraceae) stem bark and evaluation of their anti-breast cancer potential, South African Journal of Botany, 177 (2025) 445-456.

  [7]. Díaz-Ruiz G, et al. Growth inhibition of Streptococcus from the oral cavity by α-amyrin esters. Molecules. 2012 Oct 25;17(11):12603-11.  [Content Brief]