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Cyclosporin

" in MedChemExpress (MCE) Product Catalog:

79

Inhibitors & Agonists

1

Screening Libraries

104

Peptides

15

Natural
Products

3

Recombinant Proteins

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100731
    Cyclosporin

    Cyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes .
    <em>Cyclosporin</em>
  • HY-W019721
    Cyclosporin D

    		Nuclear Factor of activated T Cells (NFAT) Inflammation/Immunology
    Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .
    <em>Cyclosporin</em> D
  • HY-P1122
    Cyclosporin H
    1 Publications Verification

    		 Formyl Peptide Receptor (FPR) Infection Inflammation/Immunology
    Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
    <em>Cyclosporin</em> H
  • HY-P1354
    Cyclosporin A-Derivative 2

    		Calcineurin Others
    Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    <em>Cyclosporin</em> A-Derivative 2
  • HY-N6027
    Cyclosporin C

    		Fungal Bacterial Infection
    Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs=0.1-5 μg/ml).
    <em>Cyclosporin</em> C
  • HY-P1355
    Cyclosporin A-Derivative 1

    		Calcineurin Inflammation/Immunology
    Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    <em>Cyclosporin</em> A-Derivative 1
  • HY-P3338
    Cyclosporin A-Derivative 3

    		Phosphatase Infection
    Cyclosporin A-Derivative 3 is a derivative of Cyclosporin A (HY-B0579) with calcineurin inhibition .
    <em>Cyclosporin</em> A-Derivative 3
  • HY-N12396
    Cyclosporin U

    		Others Inflammation/Immunology
    Cyclosporin U (SMP0V32C6L) is an cytostatic agent that plays an important role in preventing rejection of transplanted organs .
    <em>Cyclosporin</em> U
  • HY-P1355A
    Cyclosporin A-Derivative 1 Free base

    		Calcineurin Others
    Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    <em>Cyclosporin</em> A-Derivative 1 Free base
  • HY-B0579
    Cyclosporin A
    Maximum Cited Publications
    97 Publications Verification

    Cyclosporine A; Ciclosporin A; CsA

    		 Molecular Glues Phosphatase Complement System Antibiotic Inflammation/Immunology Cancer
    Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
    <em>Cyclosporin</em> A
  • HY-B0579S
    Cyclosporin A-d4

    Cyclosporine A-d4; Ciclosporin A-d4; CsA-d4

    		 Antibiotic Complement System Phosphatase Inflammation/Immunology Cancer
    Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad
    <em>Cyclosporin</em> A-d4
  • HY-B0579S1
    Cyclosporin A-d3

    Cyclosporine A-d3; Ciclosporin A-d3; CsA-d3

    		 Antibiotic Complement System Molecular Glues Phosphatase Others
    Cyclosporin A-d3 is the d3-labeled Cyclosporin A (HY-B0579)[1].
    <em>Cyclosporin</em> A-d3
  • HY-B0579S2
    Cyclosporin A acetate-d4

    Cyclosporine A acetate-d4; Ciclosporin A acetate-d4; CsA acetate-d4

    		 Isotope-Labeled Compounds Calcineurin Inflammation/Immunology
    Cyclosporin A acetate-d4 (Cyclosporine A acetate-d4; Ciclosporin A acetate-d4) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
    <em>Cyclosporin</em> A acetate-d4
  • HY-B0579S3
    Cyclosporin A-13C2,d4

    Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4; CsA-13C2,d4

    		 Isotope-Labeled Compounds Calcineurin Inflammation/Immunology
    Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
    <em>Cyclosporin</em> A-13C2,d4
  • HY-W039943
    Acetyl-cyclosporin A aldehyde

    		Molecular Glues Cancer
    Acetyl-cyclosporin A aldehyde is an acetylated Cyclosporin A (HY-B0579) derivative with a reducing aldehyde group. Cyclosporin A is a potent calmodulin inhibitor and cyclophilin binder that can target the nuclear translocation of NF-AT and cause mitochondrial damage.
    Acetyl-<em>cyclosporin</em> A aldehyde
  • HY-P0025
    NIM811
    5+ Cited Publications

    (Melle-4)Cyclosporin; SDZ NIM811

    		 Mitochondrial Metabolism HCV Infection Inflammation/Immunology
    NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) .
    NIM811
  • HY-N7332
    Pepluanin A

    		P-glycoprotein Cancer
    Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport [1]
    Pepluanin A
  • HY-129072
    Isocyclosporin A

    		Others Cardiovascular Disease
    Isocyclosporin A is a degradation product of the immunosuppressant Cyclosporin A .
    Isocyclosporin A
  • HY-P0031
    Cyclo(RADfK)
    1 Publications Verification

    		 Integrin Others
    Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.
    <em>Cyclo</em>(RADfK)
  • HY-101402
    Cyclo(his-pro)

    Cyclo(histidyl-proline); Histidylproline diketopiperazine

    		 NF-κB Endogenous Metabolite Neurological Disease Inflammation/Immunology
    Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .
    <em>Cyclo</em>(his-pro)
  • HY-P0023
    Cyclo(-RGDfK)
    5+ Cited Publications

    		 Integrin Cancer
    Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
    <em>Cyclo</em>(-RGDfK)
  • HY-P0231
    AZP-531
    2 Publications Verification

    		 GHSR Metabolic Disease Endocrinology
    AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
    AZP-531
  • HY-P1934
    Cyclo(Phe-Pro)
    4 Publications Verification

    Cyclo(phenylalanylprolyl); A-64863

    		 HCV Infection
    Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses .
    <em>Cyclo</em>(Phe-Pro)
  • HY-126810A
    NP213 TFA

    		Fungal Infection
    NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
    NP213 TFA
  • HY-P0023A
    Cyclo(-RGDfK) TFA
    5+ Cited Publications

    		 Integrin Cancer
    Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
    <em>Cyclo</em>(-RGDfK) TFA
  • HY-126810
    NP213

    		Fungal Infection
    NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections .
    NP213
  • HY-107245
    Segetalin B
    1 Publications Verification

    		 Estrogen Receptor/ERR Metabolic Disease
    Segetalin B, a cyclopentapeptide from Vaccaria segetalis, possesses estrogen-like activity .
    Segetalin B
  • HY-P1934A
    Cyclo(L-Phe-L-Pro)

    		Fungal IFNAR Reactive Oxygen Species Infection Inflammation/Immunology Cancer
    Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
    <em>Cyclo</em>(L-Phe-L-Pro)
  • HY-P2300
    Cyclo(Arg-Gly-Asp-D-Phe-Cys)

    Cyclo(RGDfC)

    		 Integrin Cancer
    Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
    <em>Cyclo</em>(Arg-Gly-Asp-D-Phe-Cys)
  • HY-P1938
    Cyclo(L-Pro-L-Val)

    		Bacterial Infection
    Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .
    <em>Cyclo</em>(L-Pro-L-Val)
  • HY-P5314
    OK2

    		EGFR STAT Others
    OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research .
    OK2
  • HY-P1935
    Cyclo(Ala-​Pro)

    		Biochemical Assay Reagents Cancer
    Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .
    <em>Cyclo</em>(Ala-​Pro)
  • HY-P5038
    Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)

    c(GRGDSP)

    		 Integrin Cancer
    Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide. Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells .
    <em>Cyclo</em>(Gly-Arg-Gly-Asp-Ser-Pro)
  • HY-P5698
    Cyclopetide 1

    		Bacterial Infection
    Cyclopetide 1 (Compound 1) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 25 μg/mL .
    Cyclopetide 1
  • HY-P5699
    Cyclopetide 2

    		Bacterial Infection
    Cyclopetide 2 (Compound 2) is an antimicrobial peptide with moderate activity against B. subtilis, with a MIC of 50 μg/mL .
    Cyclopetide 2
  • HY-P10052
    CBO-P11

    		VEGFR Cancer
    CBO-P11 specifically binds to receptor of VEGFR-2 and is used as targeting ligand for tumor angiogenesis. CBO-P11 is modified with a nearinfrared cyanine dye bearing an alkyne function, allowing both “click” coupling on azido-modified nanoparticles and fluorescence labelling .
    CBO-P11
  • HY-P10222
    Cyclo(CRLLIF)

    		HIF/HIF Prolyl-Hydroxylase Cancer
    Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 14.5 and 10.2 μM, respectively .
    <em>Cyclo</em>(CRLLIF)
  • HY-P10223
    Cyclo(CRVIIF)

    		HIF/HIF Prolyl-Hydroxylase Cancer
    Cyclo CRVIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 65 and 123 μM, respectively .
    <em>Cyclo</em>(CRVIIF)
  • HY-P10221
    Cyclo(CKLIIF)

    		HIF/HIF Prolyl-Hydroxylase Cancer
    Cyclo CKLIIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively .
    <em>Cyclo</em>(CKLIIF)
  • HY-P4820A
    SYNV-cyclo(CGGYF) TFA

    		Bacterial Inflammation/Immunology
    SYNV-cyclo(CGGYF) TFA is a Staphylococcus hominis (S. hominis) C5 autoinducing peptide. SYNV-cyclo(CGGYF) TFA inhibits S. aureus activity. SYNV-cyclo(CGGYF) TFA has the potential for the research of S. aureus-mediated epithelial damage and inflammation .
    SYNV-<em>cyclo</em>(CGGYF) TFA
  • HY-P4820
    SYNV-cyclo(CGGYF)

    		Bacterial Inflammation/Immunology
    SYNV-cyclo(CGGYF) is a Staphylococcus hominis (S. hominis) C5 autoinducing peptide. SYNV-cyclo(CGGYF) inhibits S. aureus activity. SYNV-cyclo(CGGYF) has the potential for the research of S. aureus-mediated epithelial damage and inflammation .
    SYNV-<em>cyclo</em>(CGGYF)
  • HY-P3227
    Cyclo(Ala-Arg-Gly-Asp-Mamb)

    XJ735

    		 Integrin Inflammation/Immunology
    Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective RGD peptide antagonist and has the potential for Pulmonary arterial hypertension Research .
    <em>Cyclo</em>(Ala-Arg-Gly-Asp-Mamb)
  • HY-P5712
    Gramicidin S

    Gramicidin soviet

    		 Antibiotic Bacterial Infection
    Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic. Gramicidin S is active against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Gramicidin S also inhibits cytochrome bd quinol oxidase .
    Gramicidin S
  • HY-P1201
    Cyclosomatostatin

    		Somatostatin Receptor Cancer
    Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells .
    Cyclosomatostatin
  • HY-P1201A
    Cyclosomatostatin TFA

    		Somatostatin Receptor Cancer
    Cyclosomatostatin TFA is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin TFA can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells .
    Cyclosomatostatin TFA
  • HY-149205
    CXJ-2

    		PI3K ERK Inflammation/Immunology
    CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy .
    CXJ-2
  • HY-P5840
    Cyclo(RGDyC)

    		Biochemical Assay Reagents Liposome Cancer
    Cyclo(RGDyC) is a cyclic pentapeptide with anti-angiogenic abilities. Cyclo(RGDyC) can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer .
    <em>Cyclo</em>(RGDyC)
  • HY-P1613A
    Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

    Cyclo(RGDfV) TFA; C(RGDfV) TFA

    		 Integrin Apoptosis Cancer
    Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia .
    <em>Cyclo</em>(Arg-Gly-Asp-D-Phe-Val) TFA
  • HY-P1613
    Cyclo(Arg-Gly-Asp-D-Phe-Val)

    Cyclo(RGDfV); C(RGDfV)

    		 Integrin Apoptosis Cancer
    Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia .
    <em>Cyclo</em>(Arg-Gly-Asp-D-Phe-Val)
  • HY-P3557
    Mibenratide

    		Adrenergic Receptor Cardiovascular Disease
    Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research .
    Mibenratide

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