Acetyl-cyclosporin A aldehyde
Based on 1 Customer Validation
Acetyl-cyclosporin A aldehyde is an acetylated derivative of Cyclosporin A (HY-B0579) with a reducible aldehyde group. Acetyl-cyclosporin A aldehyde serves as a synthetic intermediate for the calcineurin inhibitor Voclosporin (HY-106638). Acetyl-cyclosporin A aldehyde can act as a substrate for ruthenium nanocatalyzed reductive deuteration reactions, producing the corresponding deuterated alcohol with selective deuterium incorporation at the α-position of the oxygen atom.
For research use only. We do not sell to patients.
- Purity : 99.91%
- CAS No.: 121584-52-9
- Formula: C62H109N11O14
- Molecular Weight:1232.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Acetyl-cyclosporin A aldehyde is prepared from acetylcyclosporin A via ozonolysis, followed by conversion to Voclosporin through the Peterson reaction/hydrolysis[1].
Acetyl-cyclosporin A aldehyde undergoes regioselective reductive deuteration at the α-position of the oxygen atom under 1 bar D2 atmosphere, producing 87% deuterated alcohol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 121584-52-9
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Appearance Solid
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Molecular Weight 1232.59
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Formula C62H109N11O14
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Color White to off-white
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SMILES
O=CC[C@@H](C)[C@H]([C@]1([H])N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C)C(C)C)=O)C)OC(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 4 mg/mL (3.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (296 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8113 mL | 4.0565 mL | 8.1130 mL | 20.2825 mL |
Acetyl-cyclosporin A aldehyde Related Classifications
HY-W039943 Related Classifications
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