121584-52-9
Chemical Structure
Acetyl-cyclosporin A aldehyde
- CAS No.: 121584-52-9
- Formula:C62H109N11O14
- Molecular Weight:1232.59
IUPAC Name: (1R,2R)-1-((2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-2-methyl-4-oxobutyl acetate
InChIKey: HPSRJUOXPOJSMJ-IBFGMFDFSA-N
SMILES: O=CC[C@@H](C)[C@H]([C@]1([H])N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C)C(C)C)=O)C)OC(C)=O
Biological Activity: Acetyl-cyclosporin A aldehyde is an acetylated derivative of Cyclosporin A (HY-B0579) with a reducible aldehyde group. Acetyl-cyclosporin A aldehyde serves as a synthetic intermediate for the calcineurin inhibitor Voclosporin (HY-106638). Acetyl-cyclosporin A aldehyde can act as a substrate for ruthenium nanocatalyzed reductive deuteration reactions, producing the corresponding deuterated alcohol with selective deuterium incorporation at the α-position of the oxygen atom[1][2].
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Acetyl-cyclosporin A aldehyde | 99.91% | Acetyl-cyclosporin A aldehyde is an acetylated derivative of Cyclosporin A (HY-B0579) with a reducible aldehyde group. Acetyl-cyclosporin A aldehyde serves as a synthetic intermediate for the calcineurin inhibitor Voclosporin (HY-106638). Acetyl-cyclosporin A aldehyde can act as a substrate for ruthenium nanocatalyzed reductive deuteration reactions, producing the corresponding deuterated alcohol with selective deuterium incorporation at the α-position of the oxygen atom. | ||||||||||||||||||||
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References
- [1]. Jiang B, et al. Synthesis and crystallization research of voclosporin[J]. Organic Process Research & Development, 2024, 28(4): 1151-1158.
- [2]. Martinelli E, et al. Water-Dispersible Ruthenium Nanocatalyst for Carbonyl Reduction With D or T in Aqueous Media. Angewandte Chemie (International ed. in English). 2026 Jul 13.
