cRGDfK-thioacetyl ester
Based on 1 Customer Validation
cRGDfK-thioacetyl ester is a selective αvβ3 integrin-binding peptide that mediates cellular uptake through integrins overexpressed on tumor cells. cRGDfK-thioacetyl ester is conjugated to maleimide-functionalized PLGA nanoparticles, which enhances nanoparticle uptake and improves accumulation and retention. cRGDfK-thioacetyl ester can be used in research related to tumor-targeted nanodelivery and cancer-targeted imaging.
For research use only. We do not sell to patients.
- Purity : 98.20%
- CAS No.: 393781-65-2
- Formula: C31H45N9O9S
- Molecular Weight:719.81
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
αvβ3 |
In Vitro
cRGDfK-thioacetyl ester (4 mg per 40 mg maleimide-functionalized PLGA nanoparticles; 12 h) is conjugated to maleimide-functionalized PLGA nanoparticles, yielding approximately 3,877 cRGD molecules per nanoparticle[1].
cRGDfK-thioacetyl ester-functionalized PLGA nanoparticles increase cellular uptake in NCI/ADR-RES, MCF-7, 4T1, and HUVEC cells; moreover, they exhibit higher intracellular retention than non-functionalized nanoparticles in NCI/ADR-RES cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 393781-65-2
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Appearance Solid
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Molecular Weight 719.81
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Formula C31H45N9O9S
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Color White to off-white
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Sequence
Cyclo(Arg-Gly-Asp-{d-Phe}-Lys)-{Ac-SCH2CO}
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Sequence Shortening
Cyclo(RGD-{d-Phe}-K)-{Ac-SCH2CO}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (69.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3893 mL | 6.9463 mL | 13.8926 mL | 34.7314 mL |
| 5 mM | 0.2779 mL | 1.3893 mL | 2.7785 mL | 6.9463 mL | |
| 10 mM | 0.1389 mL | 0.6946 mL | 1.3893 mL | 3.4731 mL | |
| 15 mM | 0.0926 mL | 0.4631 mL | 0.9262 mL | 2.3154 mL | |
| 20 mM | 0.0695 mL | 0.3473 mL | 0.6946 mL | 1.7366 mL | |
| 25 mM | 0.0556 mL | 0.2779 mL | 0.5557 mL | 1.3893 mL | |
| 30 mM | 0.0463 mL | 0.2315 mL | 0.4631 mL | 1.1577 mL | |
| 40 mM | 0.0347 mL | 0.1737 mL | 0.3473 mL | 0.8683 mL | |
| 50 mM | 0.0278 mL | 0.1389 mL | 0.2779 mL | 0.6946 mL | |
| 60 mM | 0.0232 mL | 0.1158 mL | 0.2315 mL | 0.5789 mL |
cRGDfK-thioacetyl ester Related Classifications
HY-P5287 Related Classifications
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