cRGDfK-thioacetyl ester TFA
Based on 1 Customer Validation
cRGDfK-thioacetyl ester TFA is a selective αvβ3 integrin-binding peptide that mediates cellular uptake through integrins overexpressed on tumor cells. cRGDfK-thioacetyl ester TFA is conjugated to maleimide-functionalized PLGA nanoparticles, which enhances nanoparticle uptake and improves accumulation and retention. cRGDfK-thioacetyl ester TFA can be used in research related to tumor-targeted nanodelivery and cancer-targeted imaging.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.30%
- Formel: C31H45N9O9S.xC2HF3O2
- Molecular Weight:719.81 (free base)
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Speicherung:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
αvβ3 |
In Vitro
cRGDfK-thioacetyl ester TFA (4 mg per 40 mg maleimide-functionalized PLGA nanoparticles; 12 h) is conjugated to maleimide-functionalized PLGA nanoparticles, yielding approximately 3,877 cRGD molecules per nanoparticle[1].
cRGDfK-thioacetyl ester TFA-functionalized PLGA nanoparticles increase cellular uptake in NCI/ADR-RES, MCF-7, 4T1, and HUVEC cells; moreover, they exhibit higher intracellular retention than non-functionalized nanoparticles in NCI/ADR-RES cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 719.81 (free base)
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Formel C31H45N9O9S.xC2HF3O2
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Color White to off-white
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Sequence
Cyclo(Arg-Gly-Asp-{d-Phe}-Lys)-{Ac-SCH2CO}
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Sequence Shortening
Cyclo(RGD-{d-Phe}-K)-{Ac-SCH2CO}
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
cRGDfK-thioacetyl ester TFA Related Classifications
HY-P5287A Related Classifications
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