Cyclo(CRLLIF)
Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 14.5 and 10.2 μM, respectively.
For research use only. We do not sell to patients.
- Formula: C36H59N9O6S
- Molecular Weight:745.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIF-2α 10.2 μM (Kd) |
HIF-1α 14.5 μM (Kd) |
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Cell Line:PANC-1, AsPC-1
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Concentration:0.1, 1, and 10 μM
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Incubation Time:12 h
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Result:Did not significantly affect the migration of AsPC-1.
Inhibited migration of PANC-1 at 1 and 10 μM.
Did not significantly affect the invasion of the two cell lines.
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Animal Model:Post-pubertal male rats[6]
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Dosage:0.3, 1.0, 3.0, 10, 30 and 100 nmol/kg
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Administration:Intraperitoneal injection (i.p.), 30 min before trunk blood and anterior pituitaries are collected
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Result:Elevated c-fos gene expression, as well as the plasma concentrations of LH and testosterone.
Showed no overall statistical effect on plasma testosterone.
Chemical Information
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Molecular Weight 745.98
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Formula C36H59N9O6S
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Sequence
Cyclo(Cys-Arg-Leu-Leu-Ile-Phe)
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Sequence Shortening
Cyclo(CRLLIF)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclo(CRLLIF) Related Classifications
HY-P10222 Related Classifications
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