Grb2 SH2 domain inhibitor 1
Based on 1 Customer Validation
Grb2 SH2 domain inhibitor 1 is an inhibitor of the Grb2 SH2 domain with an IC50 of 0.40 μM. Grb2 SH2 domain inhibitor 1 is also a cell-permeable cyclic peptide that can enter the cytosol of mammalian cells. Grb2 SH2 domain inhibitor 1 downregulates the expression level of p-MEK. Grb2 SH2 domain inhibitor 1 can be used in the research of breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.24%
- CAS No.: 3069455-54-2
- Formula: C68H95N20O15P
- Molecular Weight:1463.58
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All MEK Isoforms
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Biological Activity
Grb2 SH2 domain inhibitor 1 (Compound 14) (5 μM; 2 h) exhibits a cytoplasmic entry efficiency of 49% in HeLa cells relative to CPP9 (HY-P10644), and enters HeLa cells via an endocytic mechanism[1].
Grb2 SH2 domain inhibitor 1 (0-30 μM; 2 h) dose-dependently inhibits the level of phosphorylated MEK in EGF-stimulated MDA-MB-468 cells, with an IC50 of approximately 15 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468 human breast cancer cells
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Concentration:0, 1, 5, 15, 30 μM
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Incubation Time:2 h
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Result:Dose-dependently decreased the level of phosphorylated MEK (p-MEK) with an IC50 of ~15 μM.
Showed no effect on total MEK levels.
Exerted a less dramatic effect on ERK1/2 phosphorylation.
Chemical Information
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CAS No. 3069455-54-2
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Appearance Solid
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Molecular Weight 1463.58
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Formula C68H95N20O15P
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Color White to off-white
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Sequence
Cyclo(Tyr(PO3H2)-Arg-Arg-Pro-DPro-DArg-2Nal-Phe-Asn-Val)
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Sequence Shortening
Cyclo(Tyr(PO3H2)-RRP-DPro-DArg-2Nal-FNV)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 25 mg/mL (17.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (286 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6833 mL | 3.4163 mL | 6.8326 mL | 17.0814 mL |
| 5 mM | 0.1367 mL | 0.6833 mL | 1.3665 mL | 3.4163 mL | |
| 10 mM | 0.0683 mL | 0.3416 mL | 0.6833 mL | 1.7081 mL | |
| 15 mM | 0.0456 mL | 0.2278 mL | 0.4555 mL | 1.1388 mL |
Grb2 SH2 domain inhibitor 1 Related Classifications
HY-146127 Related Classifications
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