2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Mibenratide

Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Mibenratide Chemical Structure

Mibenratide Chemical Structure

CAS No. : 1239011-83-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Mibenratide:

Mibenratide Related Antibodies

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α adrenergic receptor β adrenergic receptor

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Description

Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research[1].

IC50 & Target

Beta-1 adrenergic receptor

 

Molecular Weight

2097.25

Formula

C87H129N27O30S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Ser-Asp-Phe-Val-Gln-Ala-Asp-Glu) (Disulfide bridge:Cys4-Cys10)
Sequence Shortening

Cyclo(ARRCYNDPKCSDFVQADE) (Disulfide bridge:Cys4-Cys10)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (47.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4768 mL 2.3841 mL 4.7681 mL
5 mM 0.0954 mL 0.4768 mL 0.9536 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4768 mL 2.3841 mL 4.7681 mL 11.9204 mL
5 mM 0.0954 mL 0.4768 mL 0.9536 mL 2.3841 mL
10 mM 0.0477 mL 0.2384 mL 0.4768 mL 1.1920 mL
15 mM 0.0318 mL 0.1589 mL 0.3179 mL 0.7947 mL
20 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.5960 mL
25 mM 0.0191 mL 0.0954 mL 0.1907 mL 0.4768 mL
30 mM 0.0159 mL 0.0795 mL 0.1589 mL 0.3973 mL
40 mM 0.0119 mL 0.0596 mL 0.1192 mL 0.2980 mL
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Mibenratide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mibenratide1239011-83-6Adrenergic ReceptorBeta Receptorheart failurecyclic peptideInhibitorinhibitorinhibit

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