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DNA+repair

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) Apoptosis (26) Arf Family GTPase (1) ATM/ATR (2) Bacterial (5) Bcl-2 Family (2) Biochemical Assay Reagents (2) c-Kit (3) c-Met/HGFR (3) c-Myc (1) Caspase (1) CDK (2) Checkpoint Kinase (Chk) (3) Cytochrome P450 (2) Deubiquitinase (1) DNA Alkylator/Crosslinker (3) DNA Glycosylase (1) DNA-PK (5) DNA/RNA Synthesis (43) Drug Derivative (4) E1/E2/E3 Enzyme (1) Endogenous Metabolite (5) Endonuclease (3) Environmental Pollutants (1) Epigenetic Reader Domain (2) ERK (2) FLAP (1) FLT3 (3) Fluorescent Dye (1) HDAC (3) Histone Acetyltransferase (1) Histone Methyltransferase (2) HIV (1) HSP (1) Isotope-Labeled Compounds (2) JAK (1) JNK (2) MDM-2/p53 (1) mRNA (1) mTOR (1) NAMPT (1) NEKs (1) NF-κB (1) p62 (1) PARP (8) PDGFR (4) Phosphatase (2) PI3K (2) Poly(ADP-ribose) Glycohydrolase (PARG) (4) PROTACs (1) Pyruvate Kinase (1) RAD51 (6) Reactive Oxygen Species (ROS) (3) Reference Standards (9) RET (3) Sirtuin (1) STAT (1) Topoisomerase (3)
By Research Areas:	Cancer (85) Cardiovascular Disease (2) Endocrinology (1) Infection (7) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (5)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	mRNA (1) Antisense Oligonucleotides (2)

107

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Saruparib 15+ Cited Publications AZD5305	PARP	Cancer
Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC₅₀ values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair .

N-Nitrosodiethylamine Maximum Cited Publications 6 Publications Verification Diethylnitrosamine; DEN; DENA	DNA/RNA Synthesis	Cancer
N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with *DNA repair/replication*. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

O6-Benzylguanine 2 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .

T2AA 2 Publications Verification	DNA/RNA Synthesis	Cancer
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .

COH34 1 Publications Verification	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC₅₀ of 0.37 nM. COH34 binds to the catalytic domain of PARG (K_d=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors .

Enterolactone	Apoptosis Endogenous Metabolite	Cancer
Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

Phleomycin 2 Publications Verification	Bacterial Antibiotic DNA/RNA Synthesis	Infection Cancer
Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research .

N-Nitrosodiethylamine-d10 Diethylnitrosamine-d₁₀; DEN-d₁₀; DENA-d₁₀	DNA/RNA Synthesis	Cancer
N-Nitrosodiethylamine-d₁₀ is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Lactobionic acid	Bacterial Reactive Oxygen Species (ROS)	Infection
Lactobionic acid is a bionic acid that can be naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties. Lactobionic acid can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .

Amuvatinib 5+ Cited Publications MP470; HPK 56	c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET Apoptosis	Cancer
Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .

AOH1160 1 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis .

(S)-Crizotinib 3 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC₅₀ of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models .

BSc5367	NEKs	Inflammation/Immunology
BSc5367 is a potent Nek1 inhibitor with an IC₅₀ of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer .

ML367 1 Publications Verification	Checkpoint Kinase (Chk)	Cancer
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation .

TNG348	Deubiquitinase JNK	Cancer
TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) .

Ro 90-7501 3 Publications Verification	Amyloid-β ATM/ATR Phosphatase Apoptosis	Neurological Disease Cancer
Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response . Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner . Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells .

YU238259	DNA-PK	Cancer
YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.

NSC16168	DNA/RNA Synthesis	Cancer
NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC₅₀ value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer .

Selenocystine 1 Publications Verification	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

Ran-IN-1	Arf Family GTPase Apoptosis	Cancer
Ran-IN-1 is a specific inhibitor of Ran GTPase. Ran-IN-1 selectively induces cytotoxicity and apoptosis in aneuploid ovarian cancer cells and also inhibits DNA repair. Ran-IN-1 exhibits antitumor activity and is useful for research on tumors such as epithelial ovarian cancer .

INO-1001 2 Publications Verification	PARP	Cancer
INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death . INO-1001 has anti-tumor effects .

NSC15520	DNA/RNA Synthesis	Cancer
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling .

Dihydralazine sulfate	Drug Derivative	Cardiovascular Disease Neurological Disease
Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia .

PDD00017272	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
PDD00017272 is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (EC₅₀=4.8 nM) and an activator of PARP1/2. PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2-dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC₅₀ of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive .

Colibactin 742	DNA Alkylator/Crosslinker	Cancer
Colibactin 742 is a covalently binding DNA-damaging agent targeting DNA, with an IC₅₀ of 5.2 μM against human cervical cancer cells (HeLa). Colibactin 742 covalently binds to DNA, forming interstrand crosslinks (ICLs), activating the Fanconi anemia DNA repair pathway, inducing γH2AX and FANCD2 foci formation and cell cycle arrest, while exacerbating mismatch repair deficiency (MMRd)-related mutations. Colibactin 742 can mimic the genotoxicity of natural Colibactin while avoiding its instability, and is mainly used in colorectal cancer (CRC) related research, including microbial tumorigenesis mechanisms, DNA damage repair pathways, and mutation signature analysis .

E7016 GPI 21016	PARP	Cancer
E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. E7016 acts as a potential anticancer agent .

Endonuclease IV	Endonuclease	Others
DNA repair enzyme. Endonuclease IV has endonuclease activity at AP sites, 3' phosphodiesterase activity that can remove a variety of ligation-blocking lesions from the 3' end of DNA, endonuclease activity on oxidative DNA lesions, and 3' to 5' exonuclease activity .

Octamethylcyclotetrasiloxane	Environmental Pollutants DNA/RNA Synthesis	Endocrinology
Octamethylcyclotetrasiloxane promotes the anchorage-independent growth of MCF-10A and MCF-10F cells. Octamethylcyclotetrasiloxane induces DNA damage, inhibits the expression of DNA-repairing protein BRCA1 under long-term and high-concentration exposure. Octamethylcyclotetrasiloxane exhibits intrinsic estrogenic activity .

KL-50	DNA/RNA Synthesis	Cancer
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O ⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O ⁶-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT .

Teglarinad chloride GMX1777; EB-1627	NAMPT	Cancer
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis .

NAD+ lithium 40+ Cited Publications β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium	Biochemical Assay Reagents	Metabolic Disease
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .

Polynucleotide kinase	DNA/RNA Synthesis	Metabolic Disease
Polynucleotide Kinase is a DNA repair enzyme. Polynucleotide Kinase possesses both a 5’-kinase activity that catalyzes the transfer of phosphate from ATP to a 5’-hydroxyl (OH) terminus and also a 3’-phosphatase activity that converts 3’-phosphate termini to 3’-OH termini .

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

MU1409	Endonuclease	Cancer
MU1409 is an inhibitor of MRE11 nuclease with an IC₅₀ of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC₅₀ values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers .

P62-RNF168 agonist-1	p62 E1/E2/E3 Enzyme Apoptosis	Cancer
P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner .

FEN1-IN-5	FLAP	Cancer
FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC₅₀=12 nM), involving in DNA repair .

Endonuclease VIII	DNA Glycosylase	Others
Endonuclease VIII is a DNA repair enzyme that excises oxidized pyrimidines from DNA. Endonuclease VIII is a bacterial DNA glycosylase/AP lyase that excises modified pyrimidines, including thymine glycol (Tg), uracil glycol, dihydrothymine, dihydrouracil (DHU) .

Exonuclease III	DNA/RNA Synthesis	Others
Exonuclease III is a nuclease for specifically targeting double-stranded DNA (dsDNA). Exonuclease III is a DNA repair-associated nuclease with apurinic/apyrimidinic (AP)-endonuclease and 3'→5' exonuclease activities. Exonuclease III cleaves the ssDNA at 5'-bond of phosphodiester from 3' to 5' end by both exonuclease and endonuclease activities .

Clofarabine-5'-triphosphate trisodium	DNA/RNA Synthesis	Cancer
Clofarabine-5'-triphosphate trisodium is the trisodium salt form of Clofarabine-5'-triphosphate (HY-164840). Clofarabine-5'-triphosphate trisodium is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-triphosphate trisodium exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .

N-Nitrosodiethylamine-d4 Diethylnitrosamine-d₄; DEN-d₄; DENA-d₄	DNA/RNA Synthesis	Cancer
N-Nitrosodiethylamine-d₄ is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Amuvatinib hydrochloride MP470 hydrochloride; HPK 56 hydrochloride	c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET	Cancer
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .

O6-Benzylguanine (Standard)	Reference Standards DNA/RNA Synthesis Apoptosis	Cancer
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .

2-Aminofluorene	DNA/RNA Synthesis	Others
2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .

LP-284	DNA Alkylator/Crosslinker	Cancer
LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL) .

2-Aminofluorene-d11	DNA/RNA Synthesis	Others
2-Aminofluorene-d₁₁ is the deuterium labeled 2-Aminofluorene . 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .

F-ara-EdU	DNA/RNA Synthesis	Cancer
F-ara-EdU is a low-toxic, highly stable probe for DNA synthesis that is used as a marker for cell proliferation and DNA replication by binding to DNA or RNA in cells. F-ara-EdU can also be used to detect the rate of DNA synthesis within cells, as well as to study the mechanisms of DNA repair and damage .

Cat. No.	Product Name

HY-L004

Cell Cycle/DNA Damage Compound Library

3,313 compounds

DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.

MCE owns a unique collection of 3,313 cell cycle/DNA damage-related compounds which can be used in the research of the same.

HY-L135

Cancer Stem Cells Compound Library

3,355 compounds

With the progress of modern cancer therapy, the life of cancer patients has been extended. However, after initial treatment and recovery, the development of secondary tumors often leads to cancer recurrence. Cancer stem cells are a small number of cells that tumor growth and reproduction depend on.

Cancer stem cells have strong self-renewal ability, which is the direct cause of tumor occurrence. In addition, cancer stem cells also have the ability to differentiate into different cell types, playing a crucial role in tumor metastasis and development. Chemotherapy and radiotherapy induced DNA damage and apoptosis are common cancer treatments. However, cancer stem cells can effectively protect cancer cells from apoptosis by activating DNA repair ability. Cancer stem cells are regarded as the key "seed" of tumor occurrence, development, metastasis and recurrence. Since its first discovery in leukemia in 1994, cancer stem cells have been considered a promising therapeutic target for cancer treatment.

MCE supplies a unique collection of 3,355 compounds targeting key proteins in cancer stem cells. MCE Cancer Stem Cells Compound Library is a useful tool for cancer stem cells related research and anti-cancer drug development.

Cat. No.	Product Name	Type

HY-D2941

BGAF SNAP-AF	Fluorescent Dyes
BGAF (SNAP-AF) is a fluorescent diacetyl fluorescein-labeled SNAP tag fluorescent probe, specifically designed for the covalent labeling of SNAP-tag fusion proteins in living cells. BGAF utilizes the specific reaction of the human DNA repair protein hAGT to achieve specific fluorescent labeling of the target protein in the living cell environment .

Cat. No.	Product Name	Type

HY-W250163

NAD+ lithium 40+ Cited Publications β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium	Biochemical Assay Reagents
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .

HY-N7059A

Lactobionic acid calcium dihydrate

Biochemical Assay Reagents

Lactobionic acid calcium dihydrate is a biomimetic acid found in Caspian yogurt, chemically composed of gluconic acid bonded to galactose. Lactobionic acid calcium dihydrate has antioxidant, antimicrobial, chelating, stabilizer, acidulant and humectant properties. Lactobionic acid calcium dihydrate can be obtained by electrolytic methods, microbial fermentation or biocatalytic approaches. Lactobionic acid calcium dihydrate can be used in foodstuffs, to produce new functional products and against food-borne pathogens. Lactobionic acid calcium dihydrate inhibits DNA repair and protein synthesis, induction of oxidative stress and inhibition of metabolic pathways against MRSA .

Cat. No.	Product Name	Target	Research Area

HY-113064

Selenocystine 1 Publications Verification	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-P10516

BRC4 peptide	DNA/RNA Synthesis RAD51	Cancer
BRC4 peptide is a specific peptide in BRCA2 protein that interacts with RAD51 protein to help repair broken DNA chains. BRC4 peptide can be used to study DNA repair mechanisms and cancer occurrence .

HY-P4161

KWWCRW	DNA/RNA Synthesis	Cancer
KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro .

HY-P10574

Phosphorylated CHKtide	Checkpoint Kinase (Chk)	Cancer
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990873

Anti-BRCA1 Antibody (BR64)	DNA/RNA Synthesis	Cancer
Anti-BRCA1 Antibody (BR64) is a kind of mouse IgG1 κ chimeric antibody, targeting to human BRCA1. Anti-BRCA1 Antibody (BR64) reacts with BRCA1 (Breast cancer susceptibility gene 1) involved in tumor suppression, transcription, genomic stability, DNA repair and recombination. Anti-BRCA1 Antibody (BR64) can be used for the detections of immunofluorescence, western blot, and immunoprecipitation in cancer, such as breast and ovarian cancer .

Species:	Human (1) E.coli (2)
Tag:	SUMO (2) His (3) Tag Free (2) Myc (1)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71512

	RecO Protein, E.coli (His-SUMO) recO; b2565; JW2549; DNA repair protein RecO; Recombination protein O	E.coli	E. coli
	RecO protein, a crucial participant in DNA repair and the RecF pathway, operates as a monomer, contributing to the intricate choreography of DNA repair mechanisms and facilitating recombination. Its monomeric form underscores its singular involvement, highlighting its significance in orchestrating cellular responses to DNA damage and recombination. RecO Protein, E.coli (His-SUMO) is the recombinant E. coli-derived RecO protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P702777

	RAD51 Protein, Human (His) DNA repair protein RAD51 homolog 1; HsRAD51; hRAD51; RAD51 homolog A; RAD51A, RECA	Human	E. coli
	RAD51 Protein, Human (His) is the recombinant human-derived RAD51, expressed by E. coli , with N-6*His labeled tag. ,

HY-P71479

	AlkB Protein, E.coli (Myc, His-SUMO) alkB; aidD; b2212; JW2200Alpha-ketoglutarate-dependent dioxygenase AlkB; EC 1.14.11.33; Alkylated DNA repair protein AlkB; DNA oxidative demethylase AlkB	E.coli	E. coli
	AlkB Protein, E.coli (Myc, His-SUMO) is a protein found in E. coli, plays a major role in oxidative dealkylation processes.

HY-P703440

	RAD51 Protein, Pyrococcus furiosus DNA repair and recombination protein RadA; radA; Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1); DNA-binding	Others	E. coli
	RAD51 Protein, Pyrococcus furiosus is the recombinant RAD51, expressed by E. coli , with tag Free labeled tag. ,

HY-P703439

	RAD51 Protein, Pyrococcus furiosus (del R288-G301) DNA repair and recombination protein RadA; radA; Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1); DNA-binding	Others	E. coli
	RAD51 Protein, Pyrococcus furiosus (del R288-G301) is the recombinant RAD51, expressed by E. coli , with tag Free labeled tag.

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Host:	Mouse (14) Rabbit (5)
Reactivity:	Human (18) Bovine (1) Rat (7) Mouse (7) Monkey (6) Dog (1) human (1)
Application:	IHC-P (6) ICC/IF (10) IF-Tissue (1) IP (9) IHC-F (3) WB (18) ChIP (2) FC (1) ELISA (2)
Isotype:	IgG (5) IgG1 (7)
Conjugation:	Non-conjugated (19)
Clonality:	Monoclonal (15) Recombinant (4)
Modification:	Unmodified (16)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81936

	Rad50 Antibody (YA1681) RAD50; DNA repair protein RAD50; hRAD50	WB	Human
	Rad50 Antibody (YA1681) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rad50.

HY-P89732

	XRCC2 Antibody (YA9076) DNA repair protein XRCC2, X-ray repair cross-complementing protein 2, XRCC2	WB	human
	XRCC2 Antibody (YA9076) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC2.

HY-P81314A

	XRCC1 Antibody (YA1059) XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	XRCC1 Antibody (YA1059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XRCC1.

HY-P81314

	XRCC1 Antibody (YA1058) XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1	WB	Human
	XRCC1 Antibody (YA1058) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC1.

HY-P85669

	XRCC4 Antibody (YA5361) XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4	WB, IHC-P, ICC/IF, IP	Human
	XRCC4 Antibody (YA5361) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to XRCC4.

HY-P81337

	XRCC4 Antibody (YA1082) X ray repair cross complementing protein 4; DNA repair protein XRCC4; DNA double strand break repair	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	XRCC4 Antibody (YA1082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC4.

HY-P81337A

	XRCC4 Antibody (YA1082)(PBS only) X ray repair cross complementing protein 4; DNA repair protein XRCC4; DNA double strand break repair	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	XRCC4 Antibody (YA1082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to XRCC4.

HY-P86467

	Rad51 Antibody (YA6159) RAD51; RAD51A; RECA; DNA repair protein RAD51 homolog 1; HsRAD51; hRAD51; RAD51 homolog A	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Rad51 Antibody (YA6159) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rad51.

HY-P87434A

	MUM1 Antibody (YA7122)(PBS only) EXPAND1, MUM1, PWWP3A, PWWP domain-containing DNA repair factor 3A, Mutated melanoma-associated antigen 1, PWWP domain-containing protein MUM1, Protein expandere, MUM-1	IHC-P, ELISA	Human
	MUM1 Antibody (YA7122) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUM1.

HY-P85527

	Rad51 Antibody (YA5219) BRCA1/BRCA2 containing complex, subunit 5; BRCC 5; BRCC5; DNA repair protein RAD51 homolog 1; DNA repair protein rhp51; HRAD51; HsRad51; HsT16930; MRMV2; Rad 51; RAD51; RAD51 homolog; RecA homolog, E. coli; S. cerevisiae; RAD51 homolog A; RAD51 homolog; RAD51 recombinase; RAD51, S. cerevisiae, homolog of; RAD51_HUMAN; RAD51A; RECA; RecA like protein; RecA, E. coli, homolog of; Recombination protein A.	WB	Human, Mouse, Rat, Monkey
	Rad51 Antibody (YA5219) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Rad51.

HY-P85476

	TFIIH p89 Antibody (YA5168) ERCC3; XPB; XPBC; TFIIH basal transcription factor complex helicase XPB subunit; Basic transcription factor 2 89 kDa subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH basal transcripti	WB	Human, Mouse, Rat, Bovine, Dog
	TFIIH p89 Antibody (YA5168) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TFIIH p89.

HY-P85570

	Rad9 Antibody (YA5262) Cell cycle checkpoint control protein; Cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD 9; hRAD9; Rad 9; RAD 9A; RAD9; S pombe; homolog; RAD9 homolog A; RAD9 homolog; RAD9A; RAD9A_HUMAN.	WB, IP	Human, Mouse, Rat, Monkey
	Rad9 Antibody (YA5262) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Rad9.

HY-P80737

	Ku80 Antibody (YA714) XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair pr	WB, ICC/IF, IP, ChIP	Human, Monkey
	Ku80 Antibody (YA714) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ku80.

HY-P85251

	Ku80 Antibody (YA4943) XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair pr	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human
	Ku80 Antibody (YA4943) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Ku80.

HY-P80737A

	Ku80 Antibody (YA714)(PBS only) XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair pr	WB, ICC/IF, IP, ChIP	Human, Monkey
	Ku80 Antibody (YA714) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ku80.

HY-P85605

	XRCC1 Antibody (YA5297) DNA repair protein XRCC1; RCC; X ray repair complementing defective repair in chinese hamster; X ray repair complementing defective repair in chinese hamster cells 1; X ray Repair Complementing Defective Repair in Chinese Hamster Cells; X ray repair cross complementing protein 1; X ray repair, complementing defective, repair in Chinese hamster; X-ray repair cross-complementing protein 1; XRCC 1; Xrcc1; XRCC1_HUMAN.	WB	Human
	XRCC1 Antibody (YA5297) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to XRCC1.

HY-P86790

	BRCA2 Antibody (YA6483) BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2, DNA repair associated antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; breast and ovarian cancer susceptibility protein 2 antibody; Breast cancer 2 early onset antibody; Breast Cancer 2 tumor suppressor antibody; Breast cancer susceptibility protein BRCA2 antibody; Breast cancer type 2 susceptibility protein antibody; BROVCA2 antibody; FACD antibody; FAD 1 antibody; FAD antibody; FAD1 antibody; FANCB antibody; FANCD 1 antibody; FANCD antibody; FANCD1 antibody; FANCD1 gene antibody; Fanconi anemia complementation group D1 antibody; Fanconi anemia group D1 protein antibody; GLM3 antibody; mutant BRCA2 antibody; OTTHUMP00000018803 antibody; OTTHUMP00000042401 antibody; PNCA2 antibody; XRCC11 antibody;	WB, FC	Human
	BRCA2 Antibody (YA6483) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRCA2.

HY-P85599

	Ku80 Antibody (YA5291) ATP dependent DNA helicase II 80 kDa subunit; ATP dependent DNA helicase II 86 Kd subunit; ATP dependent DNA helicase II; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box binding factor 85 kDa; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Double strand break rejoining; FLJ39089; G22P2; KARP 1; KARP1; Ku 80; Ku autoantigen 80kDa; Ku80; Ku86; Ku86 autoantigen related protein 1; KUB 2; KUB2; Lupus Ku autoantigen protein p86; NFIV; Nuclear factor IV; Thyroid lupus autoantigen; Thyroid-lupus autoantigen; TLAA; X ray repair complementing defective repair in Chinese hamster cells 5; double strand break rejoining; X-ray repair complementing defective repair in Chinese hamster cells 5; double-strand-break rejoining; X-ray repair cross-complementing protein 5; Xray repair complementing defective repair in Chinese hamster cells 5; XRCC 5; XRCC5; XRCC5_HUMAN.	WB, ICC/IF, IP	Human, Monkey
	Ku80 Antibody (YA5291) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ku80.

HY-P85597

	Ku70 Antibody (YA5289) 5''-deoxyribose-5-phosphate lyase Ku70; 5''-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; CTCBF; DNA repair protein XRCC6; G22P1; Ku 70; Ku autoantigen 70kDa; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku p70; Ku70; Ku70 DNA binding component of DNA-dependent proteinkinase complex; thyroid autoantigen 70 kDa; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD; Ku antigen; Thyroid autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen p70; Thyroid-lupus autoantigen; TLAA; TLAA; X ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; XRCC 6; XRCC6; XRCC6_HUMAN.	WB, ICC/IF, IP	Human, Monkey
	Ku70 Antibody (YA5289) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ku70.

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Cat. No.	Product Name		Classification

HY-W704973

F-ara-EdU		Alkynes
F-ara-EdU is a low-toxic, highly stable probe for DNA synthesis that is used as a marker for cell proliferation and DNA replication by binding to DNA or RNA in cells. F-ara-EdU can also be used to detect the rate of DNA synthesis within cells, as well as to study the mechanisms of DNA repair and damage .

Cat. No.	Product Name		Classification

HY-177631A

Etidaligide sodium DT01 sodium; coDbait sodium		Antisense Oligonucleotides
Etidaligide sodium, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation

HY-177631

Etidaligide DT01; coDbait		Antisense Oligonucleotides
Etidaligide, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation of H2A

HY-174511

Human TP53 mRNA		mRNA
Human TP53 mRNA encodes the human tumor protein p53 (TP53) protein, a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. TP53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism.

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