WJ35435
WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer.
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- No. CAS: 1620054-84-3
- Fòrmula: C20H21N3O3
- Peso molecular:351.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
0.16 μM
Compound: 41; WJ36435
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Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method
Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method
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[PMID: 33143937] |
| DU-145 | IC50 |
0.33 nM
Compound: 15; WJ35435
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Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
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[PMID: 33077264] |
| PC-3 | IC50 |
0.31 μM
Compound: 41; WJ36435
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Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method
Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method
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[PMID: 33143937] |
| PC-3 | IC50 |
0.39 nM
Compound: 15; WJ35435
|
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
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[PMID: 33077264] |
Chemical Information
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No. CAS 1620054-84-3
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Peso molecular 351.40
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Fòrmula C20H21N3O3
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SMILES
O=C(C1=CC=CC2=CC3=C(N=C21)C=CC=C3)NCCCCCC(NO)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WJ35435 Related Classifications
HY-117688 Related Classifications
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