1620054-84-3
Chemical Structure
WJ35435
- CAS No.: 1620054-84-3
- Formula:C20H21N3O3
- Molecular Weight:351.40
IUPAC Name: N-(6-(hydroxyamino)-6-oxohexyl)acridine-4-carboxamide
InChIKey: IQSOIKNMFKWXSR-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC2=CC3=C(N=C21)C=CC=C3)NCCCCCC(NO)=O
Biological Activity: WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer[1].
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WJ35435 | WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer. | |||||||||||||||||||||
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Keywords
