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Cat. No.: HY-120836

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AOH1160

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis.

For research use only. We do not sell to patients.

Purity: 98.56%

CAS No.: 2089314-57-6

Formula: C₂₅H₂₀N₂O₃

Molecular Weight:396.44

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (274 KB)

SDS

COA

AOH1160 Chemical Structure

CAS No.: 2089314-57-6

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Data Download

Data Sheet (274 KB)

SDS

COA

Handling Instructions (2659 KB)

To place orders, for customer services and technical support, please contact:

609-228-6898

[email protected] [email protected]

Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

You May Still Need

Library

Bioactive Compound Library Max

HY-L181

Library

Bioactive Compound Library

HY-L001

Library

Apoptosis Compound Library

HY-L003

Library

Cell Cycle/DNA Damage Compound Library

HY-L004

Library

Anti-Cancer Compound Library

HY-L025

Library

Anti-Aging Compound Library

HY-L034

Library

Orally Active Compound Library

HY-L061

Library

Anti-Breast Cancer Compound Library

HY-L074

Library

Anti-Lung Cancer Compound Library

HY-L075

Library

Cell Death Library

HY-L162

Library

MCE Bioactive Compound Library

HY-L001V

Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

HY-L199

Library

High-Throughput Bioactive Compound Library

HY-L205

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Publications Citing Use of MedChemExpress (MCE) AOH1160
More

bioRxiv. 2026 Feb 16.

All DNA/RNA Synthesis Isoforms
More

RNASE L

DNA Polymerases

RNA Polymerases

Helicases

DNA Ligase

Nudix hydrolas

Biological Activity

Description

IC₅₀ & Target

In Vitro

In Vivo

Chemical Information

Publications (1)

Solvent & Solubility

In Vitro

Purity & Documentation

References

Help & FAQs

Classifications

Bioz

Biological Activity

Description

AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis^[1].

IC₅₀ & Target

IC50: PCNA^[1]

All DNA/RNA Synthesis Isoforms :

RNASE L

DNA Polymerases

RNA Polymerases

Helicases

DNA Ligase

Nudix hydrolas

In Vitro

AOH1160 (500 nM, 48 h) can lead to tumor cell cycle arrest and induce tumor cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

SAEC, H524

Concentration:

500 nM

Incubation Time:

6, 24 h

Result:

Caused cell cycle arrest.
Increased in the sub-G1 population in neuroblastoma and small cell lung cancer cells.

Western Blot Analysis^[1]

Cell Line:

SAEC, H524

Concentration:

500 nM

Incubation Time:

6, 24, 48 h

Result:

Increased γH2A.X levels and activated caspase-3 and caspase-9.

In Vivo

AOH1160 (40 mg/kg, gavage once a day) can inhibit the growth of breast cancer and small cell lung cancer in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2089314-57-6

Appearance Solid

Molecular Weight 396.44

Formula C₂₅H₂₀N₂O₃

Color Off-white to light yellow

SMILES

O=C(C1=C2C=CC=CC2=CC=C1)NCC(NC3=CC=CC=C3OC4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Publications (1)

All

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Journal Impact Factor

Journal Impact Factor

Most Recent

bioRxiv

2026 Feb 16.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (252.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5224 mL

12.6122 mL

25.2245 mL

5 mM

0.5045 mL

2.5224 mL

5.0449 mL

10 mM

0.2522 mL

1.2612 mL

2.5224 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)

SDS (393 KB)

English - EN (393 KB)

Français - FR (393 KB)

Deutsch - DE (393 KB)

Norwegian - NO (393 KB)

Español - ES (393 KB)

Swedish - SV (393 KB)

Italian - IT (393 KB)

Korean - KR (393 KB)

Portuguese - PT (393 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Gu L, et al. The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.5224 mL 12.6122 mL 25.2245 mL 63.0612 mL

5 mM 0.5045 mL 2.5224 mL 5.0449 mL 12.6122 mL

10 mM 0.2522 mL 1.2612 mL 2.5224 mL 6.3061 mL

15 mM 0.1682 mL 0.8408 mL 1.6816 mL 4.2041 mL

20 mM 0.1261 mL 0.6306 mL 1.2612 mL 3.1531 mL

25 mM 0.1009 mL 0.5045 mL 1.0090 mL 2.5224 mL

30 mM 0.0841 mL 0.4204 mL 0.8408 mL 2.1020 mL

40 mM 0.0631 mL 0.3153 mL 0.6306 mL 1.5765 mL

50 mM 0.0504 mL 0.2522 mL 0.5045 mL 1.2612 mL

60 mM 0.0420 mL 0.2102 mL 0.4204 mL 1.0510 mL

80 mM 0.0315 mL 0.1577 mL 0.3153 mL 0.7883 mL

100 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6306 mL

AOH1160 Related Classifications

HY-120836 Related Classifications

Cell Cycle/DNA Damage Apoptosis

DNA/RNA Synthesis Apoptosis

Disease Areas

Cancer Inflammation or Immune System Disease Digestive System Disease

Lung Cancer Breast Cancer Digestive System Inflammation

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Powered by Bioz See more details on Bioz

Keywords

AOH1160
2089314-57-6
AOH 1160
AOH-1160
DNA/RNA Synthesis
Apoptosis
PCNA
Inhibitor
SAEC
H524
inhibitor
inhibit

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AOH1160

1 Cited Publications

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Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5224 mL	12.6122 mL	25.2245 mL	63.0612 mL
5 mM	0.5045 mL	2.5224 mL	5.0449 mL	12.6122 mL
10 mM	0.2522 mL	1.2612 mL	2.5224 mL	6.3061 mL
15 mM	0.1682 mL	0.8408 mL	1.6816 mL	4.2041 mL
20 mM	0.1261 mL	0.6306 mL	1.2612 mL	3.1531 mL
25 mM	0.1009 mL	0.5045 mL	1.0090 mL	2.5224 mL
30 mM	0.0841 mL	0.4204 mL	0.8408 mL	2.1020 mL
40 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5765 mL
50 mM	0.0504 mL	0.2522 mL	0.5045 mL	1.2612 mL
60 mM	0.0420 mL	0.2102 mL	0.4204 mL	1.0510 mL
80 mM	0.0315 mL	0.1577 mL	0.3153 mL	0.7883 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	0.6306 mL

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity

Description

IC₅₀ & Target

In Vitro

In Vivo

Chemical Information

Publications (1)

Solvent & Solubility

In Vitro

Purity & Documentation

References

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