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Cat. No.: HY-W002585R

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O6-Benzylguanine (Standard)

Name: O6-Benzylguanine (Standard)
Brand: MedChemExpress
SKU: HY-W002585R
Price: 50.00 USD
Availability: InStock
Rating: 5 (1 reviews)

O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 19916-73-5
Formula: C₁₂H₁₁N₅O
Molecular Weight:241.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

O6-Benzylguanine (Standard) Chemical Structure

CAS No.: 19916-73-5

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 19916-73-5
Molecular Weight 241.25
Formula C₁₂H₁₁N₅O
SMILES

NC(N=C1OCC2=CC=CC=C2)=NC3=C1NC=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Rabik CA, Njoku MC, Dolan ME. Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer Treat Rev. 2006;32(4):261‐276. [Content Brief]

[2]. Konduri, Santhi D et al. Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 15,19 (2009): 6087-95. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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O6-Benzylguanine (Standard)