O6-Benzylguanine (Standard)
O6-Benzylguanine Standard is the analytical standard of O6-Benzylguanine (HY-W002585). This product is intended for research and analytical applications. O6-Benzylguanine is an orally active, blood-brain barrier-penetrant inhibitor of O6-methylguanine-DNA methyltransferase (MGMT/AGT). O6-Benzylguanine modulates p53 and its downstream p21 and cyclins to induce cell cycle arrest and apoptosis, and on the other hand activates mTORC1/MAPK and other signaling pathways to induce cellular senescence by inhibiting intracellular MGMT. O6-Benzylguanine is used in research related to various tumors, cellular senescence, and vascular smooth muscle dysfunction.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 19916-73-5
- Formula: C12H11N5O
- Molecular Weight:241.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 19916-73-5
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Molecular Weight 241.25
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Formula C12H11N5O
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SMILES
NC(N=C1OCC2=CC=CC=C2)=NC3=C1NC=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Rabik CA, et al. Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer treatment reviews. 2006 Jun;32(4):261-76. [Content Brief]
[2]. Konduri SD, et al. Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Oct 01;15(19):6087-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
O6-Benzylguanine (Standard) Related Classifications
HY-W002585R Related Classifications
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Keywords
- O6-Benzylguanine (Standard)
- 19916-73-5
- Reference Standards
- DNA Methyltransferase
- Apoptosis
- MDM-2/p53
- p38 MAPK
- mTOR
- CDK
- PERK
- Caspase
- malignant glioma
- human AGT
- O6-methylguanine-DNA methyltransferase
- p53
- melanoma
- primary rat aortic VSMCs
- Rhesus monkeys
- MGMT
- pancreatic cancer
- ubiquitin-proteasome pathway
- Inhibitor
- inhibitor
- inhibit