6-O-Methyl-guanine
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6-O-Methyl-guanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 20535-83-5
- Formula: C6H7N5O
- Molecular Weight:165.16
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-HSB-2 | CC50 |
>20 μM
Compound: AMP
|
Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay
Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay
|
[PMID: 22607883] |
| HFF | CC50 |
171 μM
Compound: AMP
|
Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining
Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining
|
[PMID: 22607883] |
| HFF | IC50 |
>300 μM
Compound: AMP
|
Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining
Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining
|
[PMID: 22607883] |
| HFF | IC50 |
>300 μM
Compound: AMP
|
Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining
Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining
|
[PMID: 22607883] |
| HFF | IC50 |
2.8 μM
Compound: AMP
|
Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay
Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay
|
[PMID: 22607883] |
| HFF | IC50 |
7.4 μM
Compound: AMP
|
Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining
Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining
|
[PMID: 22607883] |
| HT-29 | ED50 |
120 μM
Compound: 7
|
Inhibitory activity against alkyl transferase in HT-29 cells
Inhibitory activity against alkyl transferase in HT-29 cells
|
[PMID: 1447749] |
| HT-29 | ED50 |
350 μM
Compound: 7
|
In vitro inhibition of human alkyl transferase in HT-29 cell-free extracts.
In vitro inhibition of human alkyl transferase in HT-29 cell-free extracts.
|
[PMID: 1447749] |
| HT-29 | IC50 |
248 μM
Compound: 1
|
concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cells
concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cells
|
[PMID: 11063604] |
| HT-29 | IC50 |
428 μM
Compound: 1
|
Inhibition of AGT activity to 50% of control rate in HT-29 cell extract
Inhibition of AGT activity to 50% of control rate in HT-29 cell extract
|
[PMID: 11063604] |
| MOLT-3 | CC50 |
>20 μM
Compound: AMP
|
Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay
Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay
|
[PMID: 22607883] |
| MOLT-3 | IC50 |
>20 μM
Compound: AMP
|
Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay
Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay
|
[PMID: 22607883] |
Chemical Information
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CAS No. 20535-83-5
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Appearance Solid
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Molecular Weight 165.16
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Formula C6H7N5O
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Color White to off-white
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SMILES
NC1=NC(OC)=C2N=CNC2=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 20 mg/mL (121.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0549 mL | 30.2744 mL | 60.5488 mL | 151.3720 mL |
| 5 mM | 1.2110 mL | 6.0549 mL | 12.1098 mL | 30.2744 mL | |
| 10 mM | 0.6055 mL | 3.0274 mL | 6.0549 mL | 15.1372 mL | |
| 15 mM | 0.4037 mL | 2.0183 mL | 4.0366 mL | 10.0915 mL | |
| 20 mM | 0.3027 mL | 1.5137 mL | 3.0274 mL | 7.5686 mL | |
| 25 mM | 0.2422 mL | 1.2110 mL | 2.4220 mL | 6.0549 mL | |
| 30 mM | 0.2018 mL | 1.0091 mL | 2.0183 mL | 5.0457 mL | |
| 40 mM | 0.1514 mL | 0.7569 mL | 1.5137 mL | 3.7843 mL | |
| 50 mM | 0.1211 mL | 0.6055 mL | 1.2110 mL | 3.0274 mL | |
| 60 mM | 0.1009 mL | 0.5046 mL | 1.0091 mL | 2.5229 mL | |
| 80 mM | 0.0757 mL | 0.3784 mL | 0.7569 mL | 1.8922 mL | |
| 100 mM | 0.0605 mL | 0.3027 mL | 0.6055 mL | 1.5137 mL |
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