6-O-Methyl-guanine

Cat. No.: HY-W013591 Pureté: 97.0%: Fiche technique
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Instruction de manipulation
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6-O-Methyl-guanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

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6-O-Methyl-guanine Chemical Structure

CAS No. : 20535-83-5

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 g	En stock	Estimated Time of Arrival: December 31
10 g	En stock	Estimated Time of Arrival: December 31
25 g	En stock	Estimated Time of Arrival: December 31
50 g	En stock	Estimated Time of Arrival: December 31
100 g	En stock	Estimated Time of Arrival: December 31
> 100 g	Obtenir un devis

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Other Forms of 6-O-Methyl-guanine:

6-O-Methyl-guanine-d₃ Obtenir un devis
6-O-Methyl-guanine (Standard) Obtenir un devis

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
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Description

6-O-Methyl-guanine is a biochemical reagent that can be used as a biological material or organic compound for life science related research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-HSB-2	CC₅₀	> 20 μM Compound: AMP	Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
HFF	CC₅₀	171 μM Compound: AMP	Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining	[PMID: 22607883]
HFF	IC₅₀	2.8 μM Compound: AMP	Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay	[PMID: 22607883]
HFF	IC₅₀	7.4 μM Compound: AMP	Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining	[PMID: 22607883]
HFF	IC₅₀	> 300 μM Compound: AMP	Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HFF	IC₅₀	> 300 μM Compound: AMP	Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HT-29	ED₅₀	120 μM Compound: 7	Inhibitory activity against alkyl transferase in HT-29 cells Inhibitory activity against alkyl transferase in HT-29 cells	[PMID: 1447749]
HT-29	ED₅₀	350 μM Compound: 7	In vitro inhibition of human alkyl transferase in HT-29 cell-free extracts. In vitro inhibition of human alkyl transferase in HT-29 cell-free extracts.	[PMID: 1447749]
HT-29	IC₅₀	248 μM Compound: 1	concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cells concentration required to reduce AGT activity to 50% of control rate in intact HT-29 human colorectal carcinoma cells	[PMID: 11063604]
HT-29	IC₅₀	428 μM Compound: 1	Inhibition of AGT activity to 50% of control rate in HT-29 cell extract Inhibition of AGT activity to 50% of control rate in HT-29 cell extract	[PMID: 11063604]
MOLT-3	CC₅₀	> 20 μM Compound: AMP	Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
MOLT-3	IC₅₀	> 20 μM Compound: AMP	Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay	[PMID: 22607883]

Masse moléculaire

165.16

Formule

C₆H₇N₅O

CAS No.

20535-83-5

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(OC)=C2N=CNC2=N1

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 20 mg/mL (121.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0549 mL	30.2744 mL	60.5488 mL
5 mM	1.2110 mL	6.0549 mL	12.1098 mL
10 mM	0.6055 mL	3.0274 mL	6.0549 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 98.92%

Select Batch:

Fiche technique (270 KB) SDS (393 KB)

COA (251 KB) HNMR (119 KB) RP-HPLC (100 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.0549 mL	30.2744 mL	60.5488 mL	151.3720 mL
	5 mM	1.2110 mL	6.0549 mL	12.1098 mL	30.2744 mL
	10 mM	0.6055 mL	3.0274 mL	6.0549 mL	15.1372 mL
	15 mM	0.4037 mL	2.0183 mL	4.0366 mL	10.0915 mL
	20 mM	0.3027 mL	1.5137 mL	3.0274 mL	7.5686 mL
	25 mM	0.2422 mL	1.2110 mL	2.4220 mL	6.0549 mL
	30 mM	0.2018 mL	1.0091 mL	2.0183 mL	5.0457 mL
	40 mM	0.1514 mL	0.7569 mL	1.5137 mL	3.7843 mL
	50 mM	0.1211 mL	0.6055 mL	1.2110 mL	3.0274 mL
	60 mM	0.1009 mL	0.5046 mL	1.0091 mL	2.5229 mL
	80 mM	0.0757 mL	0.3784 mL	0.7569 mL	1.8922 mL
	100 mM	0.0605 mL	0.3027 mL	0.6055 mL	1.5137 mL