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COH34 

Cat. No.: HY-128760
Handling Instructions

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.

For research use only. We do not sell to patients.

COH34 Chemical Structure

COH34 Chemical Structure

CAS No. : 906439-72-3

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Description

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].

IC50 & Target

IC50: 0.37 nM (PARG)[1]

In Vitro

COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].

In Vivo

COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].

Molecular Weight

293.38

Formula

C₁₈H₁₅NOS

CAS No.

906439-72-3

SMILES

CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

COH34COH 34COH-34OthersInhibitorinhibitorinhibit

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