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COH34 

Cat. No.: HY-128760 Purity: 98.25%
Handling Instructions

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.

For research use only. We do not sell to patients.

COH34 Chemical Structure

COH34 Chemical Structure

CAS No. : 906439-72-3

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].

IC50 & Target

IC50: 0.37 nM (PARG)[1]

In Vitro

COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].

In Vivo

COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].

Molecular Weight

293.38

Formula

C₁₈H₁₅NOS

CAS No.

906439-72-3

SMILES

CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4085 mL 17.0427 mL 34.0855 mL
5 mM 0.6817 mL 3.4085 mL 6.8171 mL
10 mM 0.3409 mL 1.7043 mL 3.4085 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (5.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (5.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.25%

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Keywords:

COH34COH 34COH-34OthersInhibitorinhibitorinhibit

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Product Name:
COH34
Cat. No.:
HY-128760
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