906439-72-3
906439-72-3
Chemical Structure
COH34
- CAS No.: 906439-72-3
- Formula:C18H15NOS
- Molecular Weight:293.38
IUPAC Name: (E)-1-(((p-tolylthio)imino)methyl)naphthalen-2-ol
InChIKey: SFUAIBHPGDRCFL-XDHOZWIPSA-N
SMILES: CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1
Biological Activity: COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
COH34 | 99.97% | COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
