906439-72-3
906439-72-3
Chemical Structure
COH34
- CAS No.: 906439-72-3
- Formula:C18H15NOS
- Molecular Weight:293.38
IUPAC Name: (E)-1-(((p-tolylthio)imino)methyl)naphthalen-2-ol
InChIKey: SFUAIBHPGDRCFL-XDHOZWIPSA-N
SMILES: CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1
Biological Activity: COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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COH34 | 99.97% | COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-115666COH34 analog 1 -
Similarity Score 0.69
HY-114503NSAH -
Similarity Score 0.69
HY-114503A(E/Z)-NSAH -
Similarity Score 0.64
HY-155673SLU-PP-332 -
Similarity Score 0.64
HY-100230ARML133 hydrochloride (Standard) -
Similarity Score 0.63
HY-D0324Pigment Yellow 101 -
Similarity Score 0.63
HY-1261729-Anthryldiazomethane -
Similarity Score 0.63
HY-100230ML-133 -
Similarity Score 0.63
HY-114812Anthrarobin -
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