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Cat. No.: HY-164839

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Clofarabine-5'-diphosphate

(Synonyms: Clofarabine-DP)

Clofarabine-5'-diphosphate (Clofarabine-DP) is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair.

For research use only. We do not sell to patients.

CAS No.: 167620-89-5
Formula: C₁₀H₁₃ClFN₅O₉P₂
Molecular Weight:463.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Clofarabine-5'-diphosphate Chemical Structure

CAS No.: 167620-89-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

Chemical Information

CAS No. 167620-89-5
Molecular Weight 463.64
Formula C₁₀H₁₃ClFN₅O₉P₂
SMILES

NC1=NC(Cl)=NC2=C1N=CN2[C@H]3[C@@H](F)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3
Synonyms

Clofarabine-DP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nagai S, et al., Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res. 2011 Mar 1;71(5):1781-91. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
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References

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Clofarabine-5'-diphosphate

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Clofarabine-5'-diphosphate Related Classifications

HY-164839 Related Classifications