167620-89-5
167620-89-5
Chemical Structure
Clofarabine-5'-diphosphate
Synonym(s): Clofarabine-DP
- CAS No.: 167620-89-5
- Formula:C10H13ClFN5O9P2
- Molecular Weight:463.64
InChIKey: TXRYLIWLMZYNDG-AYQXTPAHSA-N
SMILES: NC1=NC(Cl)=NC2=C1N=CN2[C@H]3[C@@H](F)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3
Biological Activity: Clofarabine-5'-diphosphate (Clofarabine-DP) is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair[1].
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Clofarabine-5'-diphosphate | Clofarabine-5'-diphosphate (Clofarabine-DP) is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair. | |||||||||||||||||||||
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References
Keywords
