1. Cell Cycle/DNA Damage
    Autophagy
  2. Nucleoside Antimetabolite/Analog
    Autophagy

Clofarabine 

Cat. No.: HY-A0005 Purity: >98.0%
Handling Instructions

Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

For research use only. We do not sell to patients.

Clofarabine Chemical Structure

Clofarabine Chemical Structure

CAS No. : 123318-82-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 73 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 66 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 165 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. IC50 Value: 65 nM Target: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. in vivo: Clofarabine is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed.

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2929 mL 16.4647 mL 32.9294 mL
5 mM 0.6586 mL 3.2929 mL 6.5859 mL
10 mM 0.3293 mL 1.6465 mL 3.2929 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

303.68

Formula

C₁₀H₁₁ClFN₅O₃

CAS No.

123318-82-1

SMILES

F[[email protected]]([[email protected]](N1C2=C(C(N)=NC(Cl)=N2)N=C1)O[[email protected]@H]3CO)[[email protected]@H]3O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Clofarabine
Cat. No.:
HY-A0005
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Clofarabine

Cat. No.: HY-A0005