1. Cell Cycle/DNA Damage
    Autophagy
  2. Nucleoside Antimetabolite/Analog
    Autophagy

Clofarabine 

Cat. No.: HY-A0005 Purity: >98.0%
Data Sheet SDS Handling Instructions

Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

For research use only. We do not sell to patients.
Clofarabine Chemical Structure

Clofarabine Chemical Structure

CAS No. : 123318-82-1

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10 mM * 1 mL in DMSO USD 87 In-stock
10 mg USD 79 In-stock
50 mg USD 198 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. IC50 Value: 65 nM Target: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. in vivo: Clofarabine is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed.

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References
Molecular Weight

303.68

Formula

C₁₀H₁₁ClFN₅O₃

CAS No.

123318-82-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Clofarabine
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HY-A0005
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