123318-82-1
123318-82-1
Chemical Structure
Clofarabine
- CAS No.: 123318-82-1
- Formula:C10H11ClFN5O3
- Molecular Weight:303.68
IUPAC Name: (2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
InChIKey: WDDPHFBMKLOVOX-AYQXTPAHSA-N
SMILES: O[C@H]1[C@H](F)[C@H](N(C=N2)C3=C2C(N)=NC(Cl)=N3)O[C@@H]1CO
Biological Activity: Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit[1].
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Clofarabine | 99.83% | Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit. | ||||||||||||||||||||
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Clofarabine (Standard) | ≥98% | Clofarabine (Standard) is the analytical standard of Clofarabine. This product is intended for research and analytical applications. Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit. | ||||||||||||||||||||
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Clofarabine solution | Clofarabine solution is mainly composed of Clofarabine (HY-A0005). Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit. | |||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.87
HY-1527782-Chloro-3’-deoxy-3’-fluoroadenosine -
Similarity Score 0.87
HY-1527732,6-Diamino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine -
Similarity Score 0.87
HY-W0115262-Amino-2'-fluoro-2'-deoxyadenosine -
Similarity Score 0.85
HY-W0083442-Chloroadenosine -
Similarity Score 0.83
HY-W0394422′-Deoxy-2′-fluoroadenosine -
Similarity Score 0.83
HY-W2516872'-Deoxy-2'-fluoroarabinoadenosine -
Similarity Score 0.83
HY-1527692-Methoxy-2’-deoxy-2’-fluoro-beta-D-arabinoadenosine -
Similarity Score 0.83
HY-1527722-Amino-6-chloropurine-9-beta-D-(2’-deoxy-2’-fluoro)-arabinoriboside -
Similarity Score 0.81
HY-1526862-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-6-methoxy-9H-purine -
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