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Results for "

IDO1 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Indoleamine 2,3-Dioxygenase (IDO) (88) Apoptosis (11) Aurora Kinase (4) Autophagy (2) Bacterial (4) Bcl-2 Family (1) Calcium Channel (1) Caspase (1) Cytochrome P450 (2) Drug Isomer (2) Endogenous Metabolite (1) Ferroptosis (2) Glutathione Peroxidase (2) HDAC (1) Heme Oxygenase (HO) (2) HIV (1) Interleukin Related (3) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) mAChR (4) Mitochondrial Metabolism (1) Molecular Glues (2) NAMPT (1) NO Synthase (2) Parasite (4) PARP (1) Potassium Channel (1) Reactive Oxygen Species (ROS) (4) Reference Standards (5) Sodium Channel (1) SWI/SNF Complex (1) TGF-β Receptor (2) TNF Receptor (2) Virus Protease (4)
By Research Areas:	Cancer (69) Cardiovascular Disease (3) Infection (8) Inflammation/Immunology (21) Metabolic Disease (5) Neurological Disease (14)

By Targets:

Indoleamine 2,3-Dioxygenase (IDO) (88)

Apoptosis (11)

Aurora Kinase (4)

Autophagy (2)

Bacterial (4)

Bcl-2 Family (1)

Calcium Channel (1)

Caspase (1)

Cytochrome P450 (2)

Drug Isomer (2)

Endogenous Metabolite (1)

Ferroptosis (2)

Glutathione Peroxidase (2)

HDAC (1)

Heme Oxygenase (HO) (2)

HIV (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

mAChR (4)

Mitochondrial Metabolism (1)

Molecular Glues (2)

NAMPT (1)

NO Synthase (2)

Parasite (4)

PARP (1)

Potassium Channel (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (5)

Sodium Channel (1)

SWI/SNF Complex (1)

TGF-β Receptor (2)

TNF Receptor (2)

Virus Protease (4)

By Research Areas:

Cancer (69)

Cardiovascular Disease (3)

Infection (8)

Inflammation/Immunology (21)

Metabolic Disease (5)

Neurological Disease (14)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Indoleamine 2,3-Dioxygenase (IDO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15689

Epacadostat Maximum Cited Publications 28 Publications Verification INCB 024360	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC₅₀ of 71.8 nM . Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.

HY-N0110

Palmatine chloride Maximum Cited Publications 9 Publications Verification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-101111

PF-06840003 1 Publications Verification EOS200271	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant *IDO-1* inhibitor with IC₅₀s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively .

HY-101560

Linrodostat 5+ Cited Publications BMS-986205; ONO-7701	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in *IDO1*-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers .

HY-111540

LY-3381916 2 Publications Verification IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of *IDO1* activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-151108

IDO1/TDO-IN-4 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Neurological Disease Inflammation/Immunology
IDO1/TDO-IN-4 is a potent *IDO1/TDO* dual inhibitor, with IC₅₀ values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π−π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders .

HY-N0353

Curdione 2 Publications Verification (+)-Curdione	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease Neurological Disease Cancer
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting *IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits* inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

HY-13983

IDO-IN-7 1 Publications Verification NLG-919 analogue; GDC-0919 analogue	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO-IN-7 (NLG-919 analogue) is a a potent *IDO1* inhibitor with an IC₅₀ of 38 nM.

HY-N0110A

Palmatine	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-177086

IDO1/TDO-IN-9	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) with IC₅₀s of <1 μM. IDO1/TDO-IN-9 inhibits the activity of IDO1 and TDO, blocking tryptophan degradation to kynurenine, restoring immune activity in the tumor microenvironment, and suppressing tumor growth. IDO1/TDO-IN-9 is promising for research of cancers .

HY-148383

DP00477	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
DP00477 is a potent IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor with an IC₅₀ value of 7.0 µM. DP00477 has the potential for the research of cancer .

HY-139204

BMS-986242 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer .

HY-144651

IDO1-IN-18	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
IDO1-IN-18 (Compound 14) is a potent inhibitor of *IDO1. IDO1-IN-18* has the potential for the research of cancer diseases .

HY-N2463

Kushenol E 1 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i of 9.5 µM, has anti-tumor activity .

HY-N0110B

Palmatine hydroxide Maximum Cited Publications 9 Publications Verification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-111540B

(S)-LY-3381916 1 Publications Verification (S)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC₅₀ value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-78699

2-Hydrazinobenzothiazole	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
2-Hydrazinobenzothiazole is a potent *IDO1* inhibitor with an IC₅₀ of 8 μM. 2-hydrazinobenzothiazole interacts with the IDO1 haem through hydrazine. 2-hydrazinobenzothiazole has the potential for immune system related diseases research .

HY-15689R

Epacadostat (Standard) INCB 024360 (Standard)	Reference Standards Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
Epacadostat (Standard) is the analytical standard of Epacadostat. This product is intended for research and analytical applications. Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC₅₀ of 71.8 nM .

HY-W113615

4-Phenyl-1H-1,2,3-triazole	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
4-Phenyl-1H-1,2,3-triazole is an *IDO1* inhibitor (IC₅₀: 60 μM). 4-Phenyl-1H-1,2,3-triazole can be used for cancer research .

HY-151978

ZC0109	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Cancer
ZC0109 is a dual inhibitor of *IDO1* and thioredoxin reductase 1 (TrxR1) with IC₅₀s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads to cancer cells apoptosis .

HY-112867

Amg-1	Indoleamine 2,3-Dioxygenase (IDO)	Cardiovascular Disease Neurological Disease Cancer
Amg-1 is a potent, reversible and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor (IC₅₀ = 3.0 μM). Amg-1 exhibits >80-fold selectivity over IDO2 (IC₅₀ > 250 μM) and >20-fold selective over TDO (IC₅₀ > 62.5 μM). Amg-1 can be used for cancer, hypotension, and neurological disorders research .

HY-112147

**IDO1 and HDAC1 Inhibitor**	Indoleamine 2,3-Dioxygenase (IDO) HDAC	Cancer
IDO1 and HDAC1 Inhibitor (Compound 10) is a dual *IDO1* and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively .

HY-145280

IDO1/2-IN-1	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1/2-IN-1 (compound 4t) is the first potent *IDO1/IDO2* dual inhibitor with IC₅₀s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active .

HY-177784

iDeg-3	Molecular Glues Indoleamine 2,3-Dioxygenase (IDO)	Infection Neurological Disease Cancer
iDeg-3 is a selective molecular glue degrader that targets *IDO1. iDeg-3 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting* the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC₅₀ = 46 nM). iDeg-3 can be used for the researches of cancer, infection and neurological disease, such as melanoma .

HY-18769

BMS-978587 1 Publications Verification IDO-IN-4	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.

HY-139205

BMT-297376	Indoleamine 2,3-Dioxygenase (IDO) Mitochondrial Metabolism	Inflammation/Immunology
BMT-297376 is an optimized derivative of Linrodostat (HY-101560). BMT-297376 inhibits *IDO1* and the ubiquinone (Q) site of mitochondrial respiratory chain complex I. BMT-297376 is suitable for tumor immunology-related research .

HY-178011

IDO1-IN-28	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-28 (Compound MQ-1) is a *Apo-IDO1* inhibitor with an IC₅₀ of 1.29  μM. IDO1-IN-28 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-28 can be used for cancers research .

HY-178024

IDO1-IN-29	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-29 (Compound MQ-1n) is a *Apo-IDO1* inhibitor with an IC₅₀ of 0.29  μM. IDO1-IN-29 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-29 can be used for cancers research .

HY-178954

IDO1-IN-32	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-32 (Compound 45) is a potent and orally effective *IDO1* inhibitor with an IC₅₀ of 10 pM. IDO1-IN-32 exhibits significant anti-proliferative activity against Hela cells. IDO1-IN-32 can significantly inhibit tumor growth in CT26 and LCC transplanted mouse models by activating anti-tumor immunity. IDO1-IN-32 can be used for research on colon cancer and breast cancer .

HY-145280A

IDO1/2-IN-1 hydrochloride	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent *IDO1/IDO2* dual inhibitor with IC₅₀s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active .

HY-178470

IDO1/TDO-IN-10	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
IDO1/TDO-IN-10 (Compound G-14) is a dual *IDO1* (EC₅₀=3.07 μM) and TDO (EC₅₀=9.7 μM) inhibitor. IDO1/TDO-IN-10 inhibits the conversion of tryptophan to kynurenine and modulates immune responses while reducing inflammatory reactions. IDO1/TDO-IN-10 is promising for research of cancers and inflammatory diseases .

HY-101560A

Linrodostat mesylate BMS-986205 mesylate; ONO-7701 mesylate	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC₅₀ value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer .

HY-148572

NAMPT/IDO1-IN-1	Indoleamine 2,3-Dioxygenase (IDO) NAMPT	Cancer
NAMPT/IDO1-IN-1 is an orally active dual inhibitor of NAMPT and *IDO1* with IC₅₀s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel (HY-B0015)- and FK866 (HY-50876)-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel .

HY-177785

iDeg-6	Molecular Glues Indoleamine 2,3-Dioxygenase (IDO)	Infection Neurological Disease Cancer
iDeg-6 is a selective molecular glue degrader that targets *IDO1* with a DC₅₀ of 6.5 nM. iDeg-6 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC₅₀ = 1.6 μM). iDeg-6 can be used for the researches of cancer, infection and neurological disease, such as melanoma .

HY-147772

ZC0101	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis Reactive Oxygen Species (ROS)	Cancer
ZC0101 is a potent, orally active *IDO1* and TrxR dual inhibitor with IC₅₀ values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells .

HY-175182

IDO1-IN-27	Indoleamine 2,3-Dioxygenase (IDO) TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
IDO1-IN-27 (Compound I-1) is a Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 0.3951  μM for recombinant hIDO1. IDO1-IN-27 also inhibits hIDO1 expression in HeLa cells (EC₅₀: 62 nM). IDO1-IN-27 effectively stimulates T cell proliferation by reducing the mRNA expression of pro-inflammatory factors (TNF-α, IL-6, and IL-1β) while concurrently inhibiting LLC cells growth .

HY-138576

IDO1-IN-26	Indoleamine 2,3-Dioxygenase (IDO)	Metabolic Disease
IDO1-IN-26 (N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(4-methyl-benzyl)-succinamic acid SA) is a *IDO1* inhibitor that can be used for the study of sarcopenia or age-related muscle loss .

HY-134920

LW106	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis SWI/SNF Complex	Cancer
LW106 is a selective *IDO1* inhibitor with an IC₅₀ of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma .

HY-N0110R

Palmatine chloride (Standard)	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR Reference Standards	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-144465

IDO1-IN-15	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-15 is a potent *IDO1* inhibitor (IC₅₀=127 nM). IDO1-IN-15 has comparable potency against IDO1 enzyme in vitro with Epacadostat .

HY-144274

IDO1-IN-14	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-14 (compound 4a) is a potent *IDO1* inhibitor with an IC₅₀ of 396.9 nM. IDO1-IN-14 has cellular IDO1 inhibition (HeLa EC₅₀=3393 nM) .

HY-144466

IDO1-IN-16	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-16 (I-1) is an *IDO1* inhibitor targeting holo-IDO1, with an IC₅₀ of 127 nM .

HY-149227

IDO1-IN-21	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-21 (compound 10m) is an *IDO1* inhibitor (IC₅₀ = 0.64 μM). IDO1-IN-21 effectively inhibits tumor growth in mice .

HY-144273

IDO1-IN-13	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-13 (compound 27a) is a potent *IDO1* inhibitor with an IC₅₀ of 61.6 nM. IDO1-IN-13 has cellular IDO1 inhibition (HeLa EC₅₀= 30 nM). IDO1-IN-13 decreases 51% of the kyn/trp ratio in SK-OV-3 xenograft tumor tissues .

HY-145355

IDO1-IN-12	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-12 is a potent and orally available *IDO1* inhibitor.

HY-145332

IDO1-IN-11	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-11 is an *IDO1* inhibitor with an IC₅₀ value of 0.6 nM.

HY-178479

IDO1-IN-30	Indoleamine 2,3-Dioxygenase (IDO) Cytochrome P450	Inflammation/Immunology Cancer
IDO1-IN-30 (Compound (R)-100) is a potent and highly selective *IDO1* inhibitor. IDO1-IN-30 has an IC₅₀ of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions .

HY-146674

IDO1/TDO-IN-3	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1/TDO-IN-3 is a potent inhibitor of *IDO1/TDO*. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC₅₀: 0.005 μM) and TDO (IC₅₀: 0.004 μM). IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed .

HY-134583

IDO1-IN-7	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC₅₀ of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer .

HY-130607

IDO1-IN-2	Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology Cancer
IDO1-IN-2 (compound 16) is a potent and selective *IDO1* inhibitor with IC₅₀s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0110

Palmatine chloride Maximum Cited Publications 9 Publications Verification	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0353

Curdione 2 Publications Verification (+)-Curdione	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Other Diseases Curcuma phaeocaulis Valeton Plants Disease Research Fields Source Classification Zingiberaceae	Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting *IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits* inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

HY-N0110A

Palmatine	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N2463

Kushenol E 1 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Moghania philippinensis (Merr. Et Rolfe) L. Plants Disease Research Fields Cancer Source Classification	Indoleamine 2,3-Dioxygenase (IDO)
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ of 7.7 µM and a K_i of 9.5 µM, has anti-tumor activity .

HY-N0110B

Palmatine hydroxide Maximum Cited Publications 9 Publications Verification	Alkaloids Phellodendron amurense Rupr. Other Alkaloids Rutaceae Plants Source Classification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110R

Palmatine chloride (Standard)	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR Reference Standards
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0353R

Curdione (Standard) (+)-Curdione (Standard)	Structural Classification Terpenoids Sesquiterpenes Curcuma phaeocaulis Valeton Plants Source Classification Zingiberaceae	Reference Standards Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) TGF-β Receptor Indoleamine 2,3-Dioxygenase (IDO)
Curdione (Standard) is the analytical standard of Curdione. This product is intended for research and analytical applications. Curdione ((+)-Curdione) is an orally active sesquiterpenoid. Curdione inhibits platelet aggregation. Curdione induces ferroptosis in colorectal cancer via m6A methylation mediated by METTL14 and YTHDF2. Curdione inhibits ferroptosis in Isoproterenol (HY-B0468)-induced myocardial infarction by regulating the Keap1/Trx1/GPX4 signaling pathway, suppressing oxidative stress (ROS) and apoptosis. Curdione ameliorates Doxorubicin (HY-15142)-induced cardiotoxicity by inhibiting oxidative stress (ROS) and activating the Nrf2/HO-1 pathway. Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation. Curdione ameliorates Bleomycin (HY-17565A)-induced pulmonary fibrosis by inhibiting TGF-β-induced fibroblast-to-myofibroblast differentiation. Curdione exhibits neuroprotective effects against focal cerebral ischemia-reperfusion injury in rats. Curdione exerts antiproliferative effects against human uterine leiomyosarcoma by targeting *IDO1. Curdione protects vascular endothelial cells and atherosclerosis by regulating DNMT1-mediated ERBB4 promoter methylation. Curdione inhibits* inducible prostaglandin E2 production (IC₅₀ = 1.1 μM) and cyclooxygenase 2 expression .

Cat. No.	Product Name	Chemical Structure

HY-W770206

IDO-IN-7-d10
IDO-IN-7-d₁₀ (NLG-919 analogue-d₁₀; GDC-0919 analogue-d₁₀) is the deuterium labeled IDO-IN-7 (HY-13983). IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC₅₀ of 38 nM.

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