1. Metabolic Enzyme/Protease
    Apoptosis
    Protein Tyrosine Kinase/RTK
  2. Indoleamine 2,3-Dioxygenase (IDO)
    Apoptosis
    ROS
  3. ZC0101

ZC0101 

Cat. No.: HY-147772
Handling Instructions

ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells.

For research use only. We do not sell to patients.

ZC0101 Chemical Structure

ZC0101 Chemical Structure

CAS No. : 2541604-52-6

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Description

ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1].

IC50 & Target

IDO1

0.084 μM (IC50)

TrxR

7.98 μM (IC50)

In Vivo

ZC0101 (60 mg/kg; p.o.; once) effectively suppresses IDO1 activity in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

293.32

Formula

C17H15N3O2

CAS No.
SMILES

O=C1C=CCCN1C(/C=C/C2=CC=CC=C2C3=CNC=N3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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ZC0101
Cat. No.:
HY-147772
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