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Art. -Nr.: HY-130607

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IDO1-IN-2

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC₅₀s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.

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CAS. Nr.: 2346614-58-0
Formel: C₁₅H₁₇FN₆O₄
Molecular Weight:364.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

IDO1-IN-2 Chemical Structure

CAS. Nr.: 2346614-58-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC₅₀s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity^[1].

IC₅₀ & Target^[1]

IDO1

81 nM (IC₅₀)

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	49 nM Compound: 79	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability by MTT assay	[PMID: 33569941]
HeLa	IC₅₀	49 nM Compound: 16	Inhibition of IDO1 in human HeLa cells stimulated with IFNgamma using L-tryptophan as substrate incubated for 48 hrs by fluorescence based assay Inhibition of IDO1 in human HeLa cells stimulated with IFNgamma using L-tryptophan as substrate incubated for 48 hrs by fluorescence based assay	[PMID: 31749906]
SW480	IC₅₀	>10 μM Compound: 16	Inhibition of TDO in human SW480 cells incubated for 48 hrs using L-tryptophan as substrate by fluorescence based assay Inhibition of TDO in human SW480 cells incubated for 48 hrs using L-tryptophan as substrate by fluorescence based assay	[PMID: 31749906]

In Vitro

IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC₅₀ of 49 nM. IDO1-IN-2 has an IC₅₀ of 249 nM for IDO1 wholr blood^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IDO1-IN-2 (100 mg/kg, twice daily) demonstrates good efficacy synergy when combined with anti-PD-1 mAb in a mouse EMT6 tumor syngeneic model^[1].
IDO1-IN-2 has a t_1/2 of 3.7 hours, a CL/CLu of 15/319 mL/min/kg, and a F of 63% for rats. IDO1-IN-2 has a t_1/2 of 6 hours, a CL/CLu of 6/88 mL/min/kg, and a F of 67% for dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2346614-58-0
Molecular Weight 364.33
Formel C₁₅H₁₇FN₆O₄
SMILES

O/N=C(N[C@H]1CC2=C1C=C(F)C=C2)/C3=NON=C3NCC(NCCO)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang H, et al.Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.ACS Med Chem Lett. 2019 Sep 18;10(11):1530-1536. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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IDO1-IN-2

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

IDO1-IN-2 Related Classifications

HY-130607 Related Classifications