1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. IDO1-IN-2

IDO1-IN-2 

Cat. No.: HY-130607
Handling Instructions

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.

For research use only. We do not sell to patients.

IDO1-IN-2 Chemical Structure

IDO1-IN-2 Chemical Structure

CAS No. : 2346614-58-0

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Description

IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity[1].

IC50 & Target[1]

IDO1

81 nM (IC50)

In Vitro

IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood[1].

In Vivo

IDO1-IN-2 (100 mg/kg, twice daily) demonstrates good efficacy synergy when combined with anti-PD-1 mAb in a mouse EMT6 tumor syngeneic model[1].
IDO1-IN-2 has a t1/2 of 3.7 hours, a CL/CLu of 15/319 mL/min/kg, and a F of 63% for rats. IDO1-IN-2 has a t1/2 of 6 hours, a CL/CLu of 6/88 mL/min/kg, and a F of 67% for dogs[1].

Molecular Weight

364.33

Formula

C₁₅H₁₇FN₆O₄

CAS No.

2346614-58-0

SMILES

O/N=C(N[[email protected]]1CC2=C1C=C(F)C=C2)/C3=NON=C3NCC(NCCO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

IDO1-IN-2Indoleamine 2,3-Dioxygenase (IDO)anti-cancerCancerImmunotherapyInhibitorinhibitorinhibit

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